Wang Jinqiang, Zhang Yuqi, Archibong Edikan, Ligler Frances S, Gu Zhen
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695, USA.
Division of Pharmacoengineering and Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Adv Biosyst. 2017 Sep;1(9):e1700084. doi: 10.1002/adbi.201700084. Epub 2017 Jul 17.
Hydrogen peroxide (H O )-responsive materials have been employed as drug delivery or diagnostic systems to treat or detect diseases with abnormal oxidative stress. A number of H O -responsive systems have been developed, and they have achieved great progress in controlled drug delivery for disease treatment. However, pathological sites with elevated H O level, such as cancer and inflammation, have their own characteristics; therefore the material structures and the subsequent formulations should be reasonably designed to acquire maximized therapeutic effects. In this progress report, we overview the development of H O -responsive functional groups for constructing H O -responsive formulations, as well as the guidance for designing suitable formulations to treat each specific pathological condition. The challenges and perspectives in this field are also discussed.
过氧化氢（H₂O₂）响应性材料已被用作药物递送或诊断系统，以治疗或检测具有异常氧化应激的疾病。已经开发了许多H₂O₂响应系统，并且它们在用于疾病治疗的可控药物递送方面取得了巨大进展。然而，H₂O₂水平升高的病理部位，如癌症和炎症，有其自身的特点；因此，应合理设计材料结构和后续制剂，以获得最大化的治疗效果。在本进展报告中，我们概述了用于构建H₂O₂响应性制剂的H₂O₂响应性功能基团的发展，以及设计适合治疗每种特定病理状况的制剂的指导原则。还讨论了该领域的挑战和前景。
