Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8601, Japan.
College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi, 487-8501, Japan.
Environ Health Prev Med. 2019 Jul 6;24(1):47. doi: 10.1186/s12199-019-0802-z.
The plasticizer di(2-ethylhexyl) phthalate (DEHP) has been widely used in the manufacture of polyvinyl chloride-containing products such as medical and consumer goods. Humans can easily be exposed to it because DEHP is ubiquitous in the environment. Recent research on the adverse effects of DEHP has focused on reproductive and developmental toxicity in rodents and/or humans. DEHP is a representative of the peroxisome proliferators. Therefore, peroxisome proliferator-activated receptor alpha (PPARα)-dependent pathways are the expected mode of action of several kinds of DEHP-induced toxicities. In this review, we summarize DEHP kinetics and its mechanisms of carcinogenicity and reproductive and developmental toxicity in relation to PPARα. Additionally, we give an overview of the impacts of science policy on exposure sources.
增塑剂邻苯二甲酸二（2-乙基己基）酯（DEHP）已广泛应用于聚氯乙烯制品的制造，如医疗和消费品。由于 DEHP 在环境中无处不在，人类很容易接触到它。最近对 DEHP 的不良影响的研究集中在啮齿动物和/或人类的生殖和发育毒性上。DEHP 是过氧化物酶体增殖物的代表。因此，过氧化物酶体增殖物激活受体α（PPARα）依赖性途径是几种 DEHP 诱导的毒性的预期作用模式。在这篇综述中，我们总结了 DEHP 的动力学及其致癌性和生殖发育毒性与 PPARα 的关系的机制。此外，我们还概述了科学政策对暴露源的影响。
