Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Nutrigenomics Research Group, Tarragona 43007, Spain.
Food Chem. 2019 Nov 30;299:125092. doi: 10.1016/j.foodchem.2019.125092. Epub 2019 Jun 27.
The health-promoting functions of fruit phenolic compounds are mainly attributed to their metabolites. The organic cultivation of fruits is becoming increasingly popular. Thus, this study evaluates whether the differences in red Grenache grapes derived from organic culture conditions influence the bioavailability and metabolism of phenolic compounds in rats. Organic and nonorganic (conventional) red Grenache grapes (OG and CG, respectively) were characterized and administered to Wistar rats (65 mg gallic acid equivalents/kg bw). Serum was recollected at different time points, and the phenolic metabolites were quantified by HPLC-ESI-MS/MS. The results showed that organic cultivation increased the oligomeric proanthocyanidin and anthocyanidin contents and decreased the content of free flavanols and dietary fiber. The serum profile of OG-administered rats showed higher metabolite concentrations at 2 h and reduced metabolite concentration at 24 h compared with the CG-administered rats. Thus, this particular serum kinetic behavior might influence the bioactivity of their phenolic compounds.
水果类多酚化合物的促进健康功能主要归因于其代谢物。水果的有机种植越来越受欢迎。因此，本研究评估了源自有机种植条件的红歌海娜葡萄的差异是否会影响大鼠体内酚类化合物的生物利用度和代谢。对有机（有机）和非有机（传统）红歌海娜葡萄（OG 和 CG）进行了特征描述，并给 Wistar 大鼠（65mg 没食子酸当量/kg bw）喂食。在不同时间点收集血清，并通过 HPLC-ESI-MS/MS 定量测定酚类代谢物。结果表明，有机种植增加了低聚原花青素和花色苷的含量，降低了游离黄烷醇和膳食纤维的含量。与 CG 处理的大鼠相比，OG 处理的大鼠血清中的代谢物浓度在 2h 时更高，而在 24h 时更低。因此，这种特殊的血清动力学行为可能会影响其酚类化合物的生物活性。
