Schmidt Anke, Bekeschus Sander
Plasma Life Science, Leibniz Institute for Plasma Science and Technology (INP Greifswald), Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.
ZIK-PRE, Leibniz Institute for Plasma Science and Technology (INP Greifswald), Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.
Antioxidants (Basel). 2018 Oct 19;7(10):146. doi: 10.3390/antiox7100146.
Chronic wounds and ulcers are major public health threats. Being a substantial burden for patients and health care systems alike, better understanding of wound pathophysiology and new avenues in the therapy of chronic wounds are urgently needed. Cold physical plasmas are particularly effective in promoting wound closure, irrespective of its etiology. These partially ionized gases deliver a therapeutic cocktail of reactive oxygen and nitrogen species safely at body temperature and without genotoxic side effects. This field of plasma medicine reanimates the idea of redox repair in physiological healing. This review compiles previous findings of plasma effects in wound healing. It discusses new links between plasma treatment of cells and tissues, and the perception and intracellular translation of plasma-derived reactive species via redox signaling pathways. Specifically, (i) molecular switches governing redox-mediated tissue response; (ii) the activation of the nuclear E2-related factor (Nrf2) signaling, together with antioxidative and immunomodulatory responses; and (iii) the stabilization of the scaffolding function and actin network in dermal fibroblasts are emphasized in the light of wound healing.
慢性伤口和溃疡是主要的公共卫生威胁。它们给患者和医疗保健系统都带来了沉重负担，因此迫切需要更好地了解伤口病理生理学以及慢性伤口治疗的新途径。冷物理等离子体在促进伤口愈合方面特别有效，无论其病因如何。这些部分电离的气体在体温下安全地提供了一种由活性氧和氮物种组成的治疗混合物，且没有基因毒性副作用。等离子体医学领域重新唤起了生理愈合中氧化还原修复的理念。本综述汇编了先前关于等离子体在伤口愈合中作用的研究结果。它讨论了等离子体对细胞和组织的处理与通过氧化还原信号通路对等离子体衍生的活性物质的感知及细胞内转化之间的新联系。具体而言，根据伤口愈合情况，强调了以下几点：(i) 控制氧化还原介导的组织反应的分子开关；(ii) 核E2相关因子 (Nrf2) 信号的激活，以及抗氧化和免疫调节反应；(iii) 真皮成纤维细胞中支架功能和肌动蛋白网络的稳定。
