Medical School, National and Kapodistrian University of Athens, Athens, Greece.
First Department of Pediatrics, Agia Sofia Children's Hospital, National and Kapodistrian University of Athens, Athens, Greece.
In Vivo. 2019 Jul-Aug;33(4):1039-1049. doi: 10.21873/invivo.11572.
Current literature indicates that there is a strong correlation between coronary artery disease (CAD) and type 2 diabetes. The arteriosclerotic progression occurs earlier and in a greater extent in the diabetic than in the non-diabetic population. In diabetic subjects, the detection of arterial disease does not always precede the development of an acute arterial incident. Herein, we reviewed studies published within the last 5 years in order to reveal the risk factors for coronary artery disease in patients with type 2 diabetes. In addition, we aimed to discuss how to diagnose in an early stage or even screen the presence of coronary artery disease in asymptomatic diabetic patients. Possible blood markers as predictors of CAD, which are mostly related to the lipidemic profile of subjects, are included in this review. Less invasive imaging methods than conventional coronary angiography, included in the article, are gradually used more in the diagnosis of CAD and show high effectiveness. Data from 23 articles with 22,350 patients having type 2 diabetes were summarized and presented descriptively.
目前的文献表明，冠状动脉疾病（CAD）与 2 型糖尿病之间存在很强的相关性。在糖尿病患者中，动脉粥样硬化的进展比非糖尿病患者更早且更严重。在糖尿病患者中，动脉疾病的检测并不总是先于急性动脉事件的发生。在此，我们回顾了过去 5 年内发表的研究，以揭示 2 型糖尿病患者患冠状动脉疾病的危险因素。此外，我们旨在讨论如何在早期阶段诊断甚至筛查无症状糖尿病患者的冠状动脉疾病。本综述纳入了可能作为 CAD 预测因子的血液标志物，这些标志物大多与患者的血脂谱有关。与传统冠状动脉造影相比，该文纳入了一些侵入性更小的成像方法，这些方法逐渐更多地用于 CAD 的诊断，并显示出很高的有效性。总结了来自 23 篇文章的 22350 例 2 型糖尿病患者的数据，并进行了描述性呈现。
