Canoso R T, de Oliveira R M
Hematology-Oncology Section, VA Medical Center, Brockton/West Roxbury, MA 02401.
Am J Hematol. 1988 Apr;27(4):272-5. doi: 10.1002/ajh.2830270408.
Anticardiolipin antibodies were determined in 96 psychiatric patients treated chronically with chlorpromazine by an enzyme-linked immunosorbent assay using anti-IgM and anti-IgG (fab'2 fragment) as the second antibody. Fifty-four of these patients had an IgM-lupus anticoagulant, and the remaining 42 were followed as controls. Elevated IgM-anticardiolipin antibodies (ACA) levels were detected in 31 patients with the lupus anticoagulant and in 5 controls (p less than 0.001). During a median followup of 5 years, single episodes of deep vein thrombosis or pulmonary embolism occurred in three patients; one had the lupus anticoagulant and the other two had low-level ACA. Contrary to the reported experience in systemic lupus erythematosus and related autoimmune disorders, chlorpromazine-induced lupus anticoagulant and anticardiolipin antibodies levels appear not to be associated with an increased incidence of thrombosis.
采用酶联免疫吸附试验，以抗IgM和抗IgG（Fab'2片段）作为第二抗体，检测了96例长期接受氯丙嗪治疗的精神科患者的抗心磷脂抗体。其中54例患者有IgM型狼疮抗凝物，其余42例作为对照进行随访。在31例有狼疮抗凝物的患者和5例对照中检测到IgM抗心磷脂抗体（ACA）水平升高（p<0.001）。在中位随访5年期间，3例患者发生了单次深静脉血栓形成或肺栓塞；1例有狼疮抗凝物，另外2例有低水平ACA。与系统性红斑狼疮及相关自身免疫性疾病的报道经验相反，氯丙嗪诱导的狼疮抗凝物和抗心磷脂抗体水平似乎与血栓形成发生率增加无关。
