Hochberg Z, Bick T, Perlman R
Department of Pediatrics, Rambam Medical Center, Technion-Israel Institute of Technology, Haifa.
Biochem Med Metab Biol. 1988 Feb;39(1):111-6. doi: 10.1016/0885-4505(88)90065-5.
To assess the relative importance of regulated and of constitutive secretion of placental lactogen, a cell culture model of term human trophoblast was utilized. Time courses of secretion revealed a constant secretion rate over 9 days of culture, with relatively small constant intracellular hormone concentration. Potassium, 21 mM, produced a slight but significant increase in hormone secretion into the medium. Growth hormone-releasing hormone (5 X 10(-10)-5 X 10(-9)) stimulated a 27-48% increase in placental lactogen secretion. The data suggest a major process of constitutive secretion and a minor role for regulated secretion from a storage pool.
为评估胎盘催乳素调节性分泌和组成性分泌的相对重要性，采用了足月人滋养层细胞培养模型。分泌的时间进程显示，在9天的培养过程中分泌速率恒定，细胞内激素浓度相对稳定且较低。21 mM的钾使培养基中激素分泌略有但显著增加。生长激素释放激素（5×10⁻¹⁰ - 5×10⁻⁹）刺激胎盘催乳素分泌增加27 - 48%。数据表明存在组成性分泌的主要过程，而来自储存池的调节性分泌作用较小。
