Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; email:
Annu Rev Cell Dev Biol. 2019 Oct 6;35:453-475. doi: 10.1146/annurev-cellbio-100818-125300. Epub 2019 Jul 5.
Macroautophagy is an intracellular degradation system that delivers diverse cytoplasmic materials to lysosomes via autophagosomes. Recent advances have enabled identification of several selective autophagy substrates and receptors, greatly expanding our understanding of the cellular functions of autophagy. In this review, we describe the diverse cellular functions of macroautophagy, including its essential contribution to metabolic adaptation and cellular homeostasis. We also discuss emerging findings on the mechanisms and functions of various types of selective autophagy.
自噬是一种细胞内降解系统，通过自噬体将各种细胞质物质输送到溶酶体。最近的进展使人们能够鉴定出几种选择性自噬底物和受体，极大地扩展了我们对自噬的细胞功能的理解。在这篇综述中，我们描述了大自噬的多种细胞功能，包括它对代谢适应和细胞内稳态的重要贡献。我们还讨论了各种类型的选择性自噬的机制和功能的新发现。
