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柬埔寨五岁以下儿童患病与营养状况的相互关系:一项纵向研究。

The Interaction between Morbidity and Nutritional Status among Children under Five Years Old in Cambodia: A Longitudinal Study.

机构信息

Reproductive and Child Health Alliance, No. 160 Street 71, Tonle Bassac, Chamkar Mon, P.O.Box 2471, Phnom Penh 12100, Cambodia.

UMR-204 Nutripass, Institut de Recherche pour le Développement, IRD/UM/SupAgro, 34390 Montpellier, France.

出版信息

Nutrients. 2019 Jul 5;11(7):1527. doi: 10.3390/nu11071527.

Abstract

Even though limited evidence is available, the relationship between morbidity and under-nutrition among children under-five is likely to be a strong two-way association. This study aims to explore this vicious cycle by employing longitudinal data of four periods within a 24 month follow-up, whereby morbidity was captured between two subsequent anthropometric measures. Malnutrition was classified according to z-scores of anthropometric measures and morbidity by number of sick days experienced inbetween. Mixed-effects models were used to assess this relation, where dependency of morbidity and nutritional status were interchanged; models were adjusted for province, age, gender, wealth index score, maternal education level, diet, and Water, Sanitation, and Hygiene indicators. Stunting and wasting prevalences were 29.9% and 8.9%, respectively, where 21.3% of the children hadmultiple anthropometric failures. Children identified as wasted were 35% more likely to experience prolonged illness periods (OR: 1.35, 95% CI: 1.02-1.56). Those experiencing high proportion of sick days were found to be 64% more likely to become stunted (OR: 1.64, 95% CI: 1.18-2.29). This study suggests that the link between wasting and stunting could be partly explained by acute illness, where wasting increases the likelihood of prolonged epiosed of illness, which increases the risk of stunting.

摘要

尽管证据有限,但五岁以下儿童的发病率和营养不足之间可能存在强烈的双向关联。本研究旨在通过使用 24 个月随访期内的四个时期的纵向数据来探索这种恶性循环,其中发病率是在两次后续人体测量之间通过患病天数来捕捉的。营养不良根据人体测量指标的 z 分数和患病天数进行分类。采用混合效应模型评估这种关系,其中发病率和营养状况的依赖性相互交换;模型根据省份、年龄、性别、财富指数得分、母亲教育水平、饮食以及水、环境卫生和个人卫生指标进行调整。发育迟缓率和消瘦率分别为 29.9%和 8.9%,其中 21.3%的儿童出现了多种人体测量失败。被诊断为消瘦的儿童患病时间延长的可能性增加 35%(OR:1.35,95%CI:1.02-1.56)。那些患病天数比例高的儿童更容易出现发育迟缓(OR:1.64,95%CI:1.18-2.29)。本研究表明,消瘦和发育迟缓之间的联系可能部分可以用急性疾病来解释,其中消瘦增加了患病时间延长的可能性,从而增加了发育迟缓的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51cc/6682948/ca97bf713ef3/nutrients-11-01527-g001.jpg

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