Department of Gynecology and Obstetrics, School of Medical Sciences, University of Campinas, (UNICAMP), Campinas, São Paulo, Brazil.
Master's Degree at Department of Gynecology and Obstetrics.
Menopause. 2019 Oct;26(10):1141-1145. doi: 10.1097/GME.0000000000001379.
To compare sleep quality and fatigue between women with premature ovarian insufficiency (POI) receiving hormone therapy (HT) and women of the same age with preserved ovarian function.
This was a cross-sectional study of 61 women with POI receiving HT (POI group) and 61 women with preserved ovarian function (control group) who were matched by age (±2 years). The Pittsburgh Sleep Quality Index (PSQI) and Chalder Fatigue Scale were used to assess sleep quality and fatigue. Apart from correlation analysis, the Mann-Whitney, chi-square, or Fisher test was used to compare the groups.
Women from the POI and control groups were 35.03 ± 7.68 and 34.49 ± 7.55 years of age, respectively (P = 0.63). In the PSQI evaluation, the scores were 7.69 ± 4.18 and 8.03 ± 4.53, respectively (P = 0.79), showing no difference between the POI and control groups. However, the POI group had higher and therefore worse scores for the sleep latency component (1.74 ± 0.66 and 1.18 ± 0.87, respectively; P < 0.001) and use of medication to sleep (1.28 ± 0.88 and 0. 85 ± 0.8; P = 0.008). The POI group had a higher fatigue index than that of the control group (5.25 ± 2.78 and 3.49 ± 1.78, respectively; P < 0.001), with sleep quality being classified as poor in 69% and fatigue present in 59% of patients.
Women with POI receiving HT have poor sleep quality. They take longer to fall asleep and have a higher fatigue index.
比较接受激素治疗（HT）的卵巢早衰（POI）女性与具有保留卵巢功能的同龄女性的睡眠质量和疲劳情况。
这是一项横断面研究，共纳入 61 名接受 HT 的 POI 女性（POI 组）和 61 名具有保留卵巢功能的女性（对照组），年龄相差 2 岁。采用匹兹堡睡眠质量指数（PSQI）和 Chalder 疲劳量表评估睡眠质量和疲劳。除相关性分析外，还采用 Mann-Whitney、卡方或 Fisher 检验比较两组。
POI 组和对照组女性的年龄分别为 35.03±7.68 岁和 34.49±7.55 岁（P=0.63）。在 PSQI 评估中，POI 组和对照组的评分分别为 7.69±4.18 和 8.03±4.53（P=0.79），两组之间无差异。然而，POI 组的睡眠潜伏期成分（1.74±0.66 和 1.18±0.87，分别；P<0.001）和用药助眠的评分更高（1.28±0.88 和 0.85±0.8；P=0.008）。POI 组的疲劳指数高于对照组（5.25±2.78 和 3.49±1.78，分别；P<0.001），69%的患者睡眠质量较差，59%的患者存在疲劳。
接受 HT 的 POI 女性睡眠质量较差，入睡时间较长，疲劳指数较高。
