Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Pedro de Toledo, 669, Vila Clementino, São Paulo, SP 04039-032, Brazil.
Psychiatry Res. 2020 Sep;291:113167. doi: 10.1016/j.psychres.2020.113167. Epub 2020 Jun 1.
A link between depression and obesity has been established by several reports. Consistent data support a bidirectional link between depression and obesity, e.g. obese people have demonstrated an increased risk of developing depression in their lifetime, whereas depressed people have shown an increased risk of becoming obese. An intensive debate in the field is that a Ca signalling dysregulation may be an upstream issue which could link obesity and depression. In fact, Ca and cAMP signalling pathways (Ca/cAMP signalling) control the release of both neurotransmitters and hormones, in addition to neuronal death and lipogenesis. Then, I herein discussed the putative contribution of Ca/cAMP signalling in this link between depression and obesity.
一些报告已经确立了抑郁和肥胖之间的联系。一致的数据支持抑郁和肥胖之间存在双向联系，例如肥胖的人一生中表现出患抑郁症的风险增加，而抑郁的人表现出肥胖的风险增加。该领域的一个激烈争论是钙信号失调可能是一个上游问题，它可以将肥胖和抑郁联系起来。事实上，钙和 cAMP 信号通路（Ca/cAMP 信号）除了控制神经元死亡和脂肪生成外，还控制神经递质和激素的释放。然后，我在这里讨论了 Ca/cAMP 信号在抑郁和肥胖之间的这种联系中的可能作用。
