Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Rua Pedro de Toledo, 669, Vila Clementino, Sao Paulo, SP, Brazil.
Anticancer Agents Med Chem. 2020;20(7):777-782. doi: 10.2174/1871520620666200220113817.
Limitations on the pharmacotherapy and a high prevalence worldwide are critical issues related to depression and cancer. It has been discussed that a dysregulation of intracellular Ca2+ homeostasis is involved in the pathogenesis of both these diseases. In addition, depression raises the risk of cancer incidence. Consistent data support the concept that depression is an independent risk issue for cancer. However, the cellular mechanisms involved in this link between depression and cancer remain uncertain. Considering our previous reports about Ca2+ and cAMP signalling pathways (Ca2+/cAMP signalling), I herein discussed the putative contribution of Ca2+/cAMP signalling in this link between depression and cancer. Moreover, it is important to take depression into account during the process of prevention and treatment of cancer.
抑郁症与癌症相关的局限性和全球高发率是关键问题。据讨论，细胞内 Ca2+ 稳态失调与这两种疾病的发病机制有关。此外，抑郁症会增加癌症发病率。一致的数据支持这样一种观点，即抑郁症是癌症的独立风险因素。然而，抑郁症与癌症之间联系的细胞机制仍不确定。考虑到我们之前关于 Ca2+ 和 cAMP 信号通路（Ca2+/cAMP 信号）的报告，我在此讨论了 Ca2+/cAMP 信号在抑郁症与癌症之间联系中的可能作用。此外，在癌症的预防和治疗过程中，考虑到抑郁症是很重要的。
