Keragala B S D P, Herath H M M T B, Keragala T S, Malavi M A M H, Rodrigo Chaturaka, Gunasekera C N
National Hospital of Sri Lanka, Colombo, Sri Lanka.
Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, 2052, Australia.
BMC Dermatol. 2019 Jul 10;19(1):10. doi: 10.1186/s12895-019-0090-8.
Patch testing with a baseline series is a common tool employed when the sensitizing agent in contact dermatitis is unclear. However, for Asian countries, there are no locally validated baseline series to utilize in screening.
We completed a retrospective analysis of all patients that had undergone patch testing with the European Baseline series, Shoe Series or Comprehensive International Baseline series, over 7 years from 2012 to 2018 in a tertiary care reference dermatology clinic in Sri Lanka to evaluate the suitability of these investigations to identify causes for contact dermatitis in the local study population.
Out of 438 patients tested, 239 (54.8%) reacted to at least one substance in the series. The Shoe Series was significantly more likely to yield a positive result than the European Baseline Series (70.2% vs 46.9%, p < 0.05). The top three sensitizers identified by all series were nickel sulfate (16%, 70/438), p-phenylenediamine (12.3%, 54/438) and 2-mercaptobenzothiazole or mercapto mix (10.5%, 46/438).
Shoe series has a comparatively high yield in the local population compared to European Baseline series. Since little less than half of the study population did not have any reactivity to any of the allergens tested it is important to develop or modify and validate a locally relevant, more suitable baseline series which is based on the Shoe Series in Sri Lanka. This is further evidence for the continuously changing nature of allergens in the environment and the need to modify existing patch testing standards accordingly.
当接触性皮炎的致敏剂不明时，使用基础系列进行斑贴试验是一种常用方法。然而，在亚洲国家，尚无经过本地验证的基础系列可用于筛查。
我们对2012年至2018年7年间在斯里兰卡一家三级医疗参考皮肤科诊所接受欧洲基础系列、鞋类系列或综合国际基础系列斑贴试验的所有患者进行了回顾性分析，以评估这些检测方法在确定当地研究人群接触性皮炎病因方面的适用性。
在438名接受检测的患者中，239名（54.8%）对该系列中的至少一种物质有反应。鞋类系列产生阳性结果的可能性显著高于欧洲基础系列（70.2%对46.9%，p<0.05）。所有系列确定的前三种致敏剂为硫酸镍（16%，70/438）、对苯二胺（12.3%，54/438）和2-巯基苯并噻唑或巯基混合物（10.5%，46/438）。
与欧洲基础系列相比，鞋类系列在当地人群中的阳性率较高。由于不到一半的研究人群对所检测的任何过敏原均无反应，因此开发或修改并验证基于斯里兰卡鞋类系列的、与当地相关且更合适的基础系列非常重要。这进一步证明了环境中过敏原性质的不断变化以及相应修改现有斑贴试验标准的必要性。
