Kiss I, Beaton A H, Tardiff J, Fristrom D, Fristrom J W
Department of Genetics, University of California, Berkeley 94720.
Genetics. 1988 Feb;118(2):247-59. doi: 10.1093/genetics/118.2.247.
The 2B5 region on the X chromosome of Drosophila melanogaster forms an early ecdysone puff at the end of the third larval instar. The region contains a complex genetic locus, the Broad-Complex (BR-C) composed of four groups of fully complementing (br, rbp, l(1)2Bc, and l(1)2Bd) alleles, and classes of noncomplementing (npr 1) and partially noncomplementing l(1)2Bab alleles. BR-C mutants prevent metamorphosis, including the morphogenesis of imaginal discs. Results are presented that indicate that the BR-C contains two major functional domains. One, the br domain is primarily, if not exclusively, involved in the elongation and eversion of appendages by imaginal discs. The second, the l(1)2Bc domain, is primarily involved in the fusion of discs to form a continuous adult epidermis. Nonetheless, the two domains may encode products with related functions because in some situations mutants in both domains appear to affect similar developmental processes.
果蝇X染色体上的2B5区域在第三龄幼虫末期形成一个早期蜕皮激素胀泡。该区域包含一个复杂的遗传位点，即由四组完全互补（br、rbp、l(1)2Bc和l(1)2Bd）等位基因组成的Broad-Complex（BR-C），以及非互补（npr 1）和部分非互补的l(1)2Bab等位基因类别。BR-C突变体阻止变态，包括成虫盘的形态发生。研究结果表明，BR-C包含两个主要功能域。一个是br域，主要（如果不是唯一的话）参与成虫盘对附肢的伸长和外翻。第二个是l(1)2Bc域，主要参与盘的融合以形成连续的成虫表皮。尽管如此，这两个域可能编码具有相关功能的产物，因为在某些情况下，两个域中的突变体似乎会影响相似的发育过程。
