Baratta Francesca, Simiele Marco, Pignata Irene, Ravetto Enri Lorenzo, Torta Riccardo, De Luca Anna, Collino Massimo, D'Avolio Antonio, Brusa Paola
Department of Drug Science and Technology, University of Turin, Turin, Italy.
Laboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical Sciences, University of Turin, ASL Città Di Torino, Amedeo di Savoia Hospital, Turin, Italy.
Front Pharmacol. 2019 Jun 25;10:701. doi: 10.3389/fphar.2019.00701. eCollection 2019.
Under current legislation in Italy, for medical purposes may be administered orally in the form of decoction or oil extract. The scientific literature reports a number of preparation methods, mainly for oils, but no study is available that compares thoroughly, from a technological viewpoint, the -based formulations currently administered to patients. With this in mind, this research work aimed to carry out specific formulation studies to design standard operating procedures for the preparation and optimization of -based galenic formulations. Both decoctions and oils were prepared under different operating conditions to identify the most efficient process for the production of formulations with a high concentration of decarboxylated delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Regarding oil, a new procedure has been developed that allows significantly higher recovery rates for THC and CBD compared with those for water-based extraction methods (decoction) and those for oil-based methods currently in use. Moreover, based on the results, it is possible to affirm that the prescription of -based decoctions should not be the recommended first-choice solution for therapy, considering the low concentration of THC and CBD and, consequently, the high volume of decoction that the patient would have to ingest.
根据意大利现行法律，出于医疗目的，可采用汤剂或油提取物的形式口服给药。科学文献报道了多种制备方法，主要是针对油类的，但尚无研究从技术角度全面比较目前给患者使用的基于[此处原文缺失相关物质名称]的制剂。考虑到这一点，本研究工作旨在开展特定的制剂研究，以设计基于[此处原文缺失相关物质名称]的盖仑制剂的制备和优化标准操作规程。汤剂和油类均在不同操作条件下制备，以确定生产具有高浓度脱羧δ-9-四氢大麻酚（THC）和大麻二酚（CBD）的制剂的最有效工艺。关于[此处原文缺失相关物质名称]油，已开发出一种新方法，与水基提取法（汤剂）和目前使用的油基方法相比，该方法可显著提高THC和CBD的回收率。此外，根据结果可以确定，考虑到THC和CBD的浓度较低，因此患者必须摄入的汤剂体积较大，基于[此处原文缺失相关物质名称]的汤剂不应作为推荐的首选治疗方案。
