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医用大麻:使使用与循证医学方法保持一致。

Medical cannabis: aligning use to evidence-based medicine approach.

机构信息

Cannabis Clinical Research Institute, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel.

出版信息

Br J Clin Pharmacol. 2018 Nov;84(11):2458-2462. doi: 10.1111/bcp.13657. Epub 2018 Aug 28.

Abstract

During the past decade we have been witnessing a rise in medical cannabis use, yet the evidence for the safety and efficacy of the various cannabinoid compounds is scarce. The State of Israel has always been at the forefront of clinical and translational research in support of Evidence Based Medicine. With respect to cannabis Israel has created a medical and regulatory environment that enables clinical studies with cannabis which may lead to improved Evidence Based use of these compounds. This opinion paper discusses selected studies into the safety and effects of cannabis derived products.

摘要

在过去的十年中,我们见证了医用大麻使用的增加,但各种大麻素化合物的安全性和疗效证据却很少。以色列在支持循证医学的临床和转化研究方面一直处于领先地位。在大麻方面,以色列创造了一个医疗和监管环境,使对大麻衍生产品的安全性和效果进行临床研究成为可能,这可能会导致这些化合物的使用更加循证。本文讨论了一些关于大麻素产品的安全性和效果的研究。

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本文引用的文献

1
Medical Cannabis for Pediatric Moderate to Severe Complex Motor Disorders.
J Child Neurol. 2018 Aug;33(9):565-571. doi: 10.1177/0883073818773028. Epub 2018 May 16.
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Medical Cannabis in Parkinson Disease: Real-Life Patients' Experience.帕金森病中的医用大麻:真实患者的体验
Clin Neuropharmacol. 2017 Nov/Dec;40(6):268-272. doi: 10.1097/WNF.0000000000000246.
7
Incretin secretion in humans is under the influence of cannabinoid receptors.人体内的肠促胰岛素分泌受大麻素受体的影响。
Am J Physiol Endocrinol Metab. 2017 Sep 1;313(3):E359-E366. doi: 10.1152/ajpendo.00080.2017. Epub 2017 Jun 27.

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