Alshathly Mona R
Department of Biological Sciences, Faculty of Science, Northern Border University, Arar, Saudi Arabia.
Department of Biology, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
J Microsc Ultrastruct. 2019 Apr-Jun;7(2):91-101. doi: 10.4103/JMAU.JMAU_16_19.
Ginger () was reported to have an antioxidant, antidiabetic effect. This study was done to investigate its therapeutic effect against functional and structural alteration in liver of diabetic rat (intraperitoneal streptozotocin (STZ) in a dose of 60 mg/kg/bw). Thirty adult male rats (three-months-old and 250 g weight) were sorted into five groups (=6). G1 used as control, G2 was diabetic rats without any treatment, G3 was diabetic rats given oral ginger in a dose of 500 mg/kg/bw, G4 was diabetic rats treated with metformin (500 mg/kg/bw) while G5 received ginger orally. The experiment lasts for six weeks, animals were anesthetized by ether, body weight was recorded for all animals. Blood was collected for further analysis of lipid profile, liver enzymes and total antioxidant. Liver was dissected, weighted and samples were processed for histopathological study. The results showed significant decrease of glaucous level and liver enzymes in ginger treated rats. Total antioxidant was preserved. Ginger lowered blood glucose, level, regained body weight and liver index to near normal values. Diabetes induced degenerative changes and micro-vesicular lipid deposition in hepatocytes with moderate portal area fibrosis. Ultrastructure study confirmed such changes beside demonstrating increased lipid deposition in fat storing cells. Ginger was found to ameliorate those changes in treated animals. Results were matching metformin effects. In conclusion, Ginger as a natural safe Herbal medication can be used to support liver functions in diabetic status.
据报道，生姜具有抗氧化、抗糖尿病作用。本研究旨在探讨其对糖尿病大鼠肝脏功能和结构改变的治疗效果（腹腔注射链脲佐菌素（STZ），剂量为60mg/kg体重）。将30只成年雄性大鼠（3个月大，体重250g）分为五组（每组6只）。G1组作为对照组，G2组为未接受任何治疗的糖尿病大鼠，G3组为口服生姜剂量为500mg/kg体重的糖尿病大鼠，G4组为用二甲双胍（500mg/kg体重）治疗的糖尿病大鼠，而G5组口服生姜。实验持续6周，用乙醚麻醉动物，记录所有动物的体重。采集血液用于进一步分析血脂、肝酶和总抗氧化剂。解剖肝脏，称重，并对样本进行组织病理学研究。结果显示，生姜治疗组大鼠的血糖水平和肝酶显著降低。总抗氧化剂得以保留。生姜降低了血糖水平，恢复了体重和肝脏指数至接近正常水平。糖尿病导致肝细胞发生退行性改变和微泡性脂质沉积，并伴有中度门静脉区纤维化。超微结构研究证实了这些变化，同时显示脂肪储存细胞中的脂质沉积增加。在治疗动物中发现生姜可改善这些变化。结果与二甲双胍的作用相符。总之，生姜作为一种天然安全的草药药物，可用于支持糖尿病状态下的肝脏功能。
