Al-Noory Ahmad Sameer, Amreen Abdul-Nasser, Hymoor Shatha
Department of Pharmacognosy and Medical Plants, Damascus University, Syria.
Pharmacognosy Res. 2013 Jul;5(3):157-61. doi: 10.4103/0974-8490.112419.
Diabetic mellitus and hypothyroidism lead to serum lipoproteins disorders. This study aims to investigate the potential effect of fresh ginger extracts Zingiber officinale roscoe (Family: Zingebiraceae) on serum lipid profile and on blood glucose in alloxan-induced diabetes and propylthiouracil-induced hypothyroidism in rats. Rats were divided into 11 groups: The normal G1, diabetic control rats G2, ginger 500 mg/kg treated diabetic rats G3, 10 mg/day atorvastatine-treated diabetic rats G4, [5 mg/day atorvastatine combined with 500 mg/kg ginger] treated diabetic rats G5, glibenclamid-treated diabetic rats G6, hypothyoidism control rats G7, 300 mg/kg ginger-treated hypothyroidism rats G8, 500 mg/kg ginger-treated hypothyroidism rats G9, 10 mg/day atorvastatine-treated hypothyroidism rats G10, [atorvastatine combined with 500 mg/kg ginger]treated hypothyroidism rats G11. Thirty days after treatment, samples were collected, to compare treated groups with normal and control groups, using Mann-Whitney U test P < 0.01.
It revealed a decrease in the levels of total cholesterol (TC), and low density lipoprotein (LDL) in the serum of rats that were treated by ginger extracts, compared with the control groups. Previous extracts were also able to cause reduction in LDL to similar levels compared to normal group and that was the same effect of atorvastatin 10 mg/day. Combined effect was clear between the act of ginger at a dose of 500 mg/kg and atorvastatin; that levels of both TC and LDL in animals which received [atorvastatin 5 mg/day combined with ginger extract] was almost equal to levels in animals that received atorvastatin 10mg/day. Clear reduce in triglyceride, and clear increase in high density liopprotein were also recorded in the ginger-treated groups. Ginger was more active in hypothyroidism rats than in diabetic rats in reducing LDL and TC. Glucose levels were substantially reduced in ginger- treated diabetic groups.
糖尿病和甲状腺功能减退会导致血清脂蛋白紊乱。本研究旨在探讨新鲜生姜提取物姜（姜科）对四氧嘧啶诱导的糖尿病大鼠和丙硫氧嘧啶诱导的甲状腺功能减退大鼠的血脂谱和血糖的潜在影响。将大鼠分为11组：正常组G1、糖尿病对照组大鼠G2、500mg/kg生姜治疗的糖尿病大鼠G3、10mg/天阿托伐他汀治疗的糖尿病大鼠G4、[5mg/天阿托伐他汀与500mg/kg生姜联合]治疗的糖尿病大鼠G5、格列本脲治疗的糖尿病大鼠G6、甲状腺功能减退对照组大鼠G7、300mg/kg生姜治疗的甲状腺功能减退大鼠G8、500mg/kg生姜治疗的甲状腺功能减退大鼠G9、10mg/天阿托伐他汀治疗的甲状腺功能减退大鼠G10、[阿托伐他汀与500mg/kg生姜联合]治疗的甲状腺功能减退大鼠G11。治疗30天后，采集样本，使用曼-惠特尼U检验（P<0.01）将治疗组与正常组和对照组进行比较。
与对照组相比，生姜提取物治疗的大鼠血清中总胆固醇（TC）和低密度脂蛋白（LDL）水平降低。与正常组相比，先前的提取物也能够使LDL降低到相似水平，这与10mg/天阿托伐他汀的效果相同。500mg/kg剂量的生姜与阿托伐他汀之间的联合作用明显；接受[5mg/天阿托伐他汀与生姜提取物联合]的动物的TC和LDL水平几乎等于接受10mg/天阿托伐他汀的动物的水平。生姜治疗组的甘油三酯明显降低，高密度脂蛋白明显升高。在降低LDL和TC方面，生姜在甲状腺功能减退大鼠中比在糖尿病大鼠中更有效。生姜治疗的糖尿病组血糖水平大幅降低。
