Institute of Neuroscience, University of Oregon, Eugene, Oregon.
Stowers Institute for Medical Research, Kansas City, Missouri.
Zebrafish. 2019 Oct;16(5):469-476. doi: 10.1089/zeb.2019.1760. Epub 2019 Jul 11.
To adequately connect zebrafish medical models to human biology, it is essential that gene nomenclature reflects gene orthology. Analysis of gene phylogenies and conserved syntenies shows that the zebrafish gene currently called (ENSDARG00000004256, ZFIN ID: ZDB-GENE-990603-12) is not the ortholog of the human gene called (ENSG00000085741); instead, the gene currently called (ENSDARG00000014796, ZFIN ID: ZDB-GENE-980526-249) is the zebrafish ortholog of human Genomic analysis of family genes suggests a model for the birth of family gene ohnologs in genome duplication events, provides a mechanism for the death of a family ohnolog in mammals after they diverged from birds, and suggests revised nomenclature to better connect teleost disease models to human biology.
为了使斑马鱼医学模型与人类生物学充分关联,基因命名法必须反映基因的同源性。基因系统发育和保守同线性分析表明,目前被称为(ENSDARG00000004256,ZFIN ID:ZDB-GENE-990603-12)的斑马鱼基因不是被称为(ENSG00000085741)的人类基因的同源物;相反,目前被称为(ENSDARG00000014796,ZFIN ID:ZDB-GENE-980526-249)的基因是人类的斑马鱼同源物。对家族基因的基因组分析为基因组复制事件中家族基因同源物的诞生提供了模型,为哺乳动物与鸟类分化后家族同源物的死亡提供了机制,并提出了修订后的命名法,以更好地将硬骨鱼疾病模型与人类生物学联系起来。