Baye Estifanos, Mark Alicja B, Poulsen Malene W, Andersen Jeanette M, Dragsted Lars O, Bügel Sussane G, de Courten Barbora
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3168, Australia.
Department of Nutrition, Exercise and Sports, University of Copenhagen, 1165 København, Denmark.
J Clin Med. 2019 Jul 10;8(7):1008. doi: 10.3390/jcm8071008.
Advanced glycation end products (AGEs) have been implicated in the pathophysiology of type 2 diabetes and cardiovascular disease. We aimed to determine the associations of urinary carboxymethyl-lysine (CML) and methylglyoxal-hydroimidazolone (MG-H1) levels with cardiometabolic parameters in metabolically healthy obese women. Anthropometric, glycemic, cardiovascular, and urinary AGE parameters were measured in 58 metabolically healthy obese women (age: 39.98 ± 8.72 years; body mass index (BMI): 32.29 ± 4.05 kg/m). Urinary CML levels were positively associated with BMI ( = 0.29, = 0.02). After adjustment for age and BMI, there was a trend for positive associations between urinary CML levels and fasting ( = 0.06) and 2 h insulin ( = 0.05) levels, and insulin resistance measured by homeostatic model assessment (HOMA-IR) ( = 0.06). Urinary MG-H1 levels were positively associated with systolic and diastolic blood pressure, pulse pressure, mean arterial pressure, and total and low-density lipoprotein cholesterol after adjustment for age, BMI, and HOMA-IR (all ˂ 0.05). There were no associations between urinary CML levels and cardiovascular parameters, and between urinary MG-H1 levels and glycemic measurements. Our data support a role of urinary AGEs in the pathophysiology of insulin resistance and cardiovascular disease; however, future studies are highly warranted.
晚期糖基化终末产物（AGEs）与2型糖尿病和心血管疾病的病理生理学有关。我们旨在确定代谢健康的肥胖女性中尿羧甲基赖氨酸（CML）和甲基乙二醛-氢咪唑酮（MG-H1）水平与心脏代谢参数之间的关联。对58名代谢健康的肥胖女性（年龄：39.98±8.72岁；体重指数（BMI）：32.29±4.05kg/m²）进行了人体测量、血糖、心血管和尿AGE参数测量。尿CML水平与BMI呈正相关（r = 0.29，P = 0.02）。在调整年龄和BMI后，尿CML水平与空腹血糖（r = 0.06）、2小时胰岛素（r = 0.05）水平以及通过稳态模型评估（HOMA-IR）测量的胰岛素抵抗（r = 0.06）之间存在正相关趋势。在调整年龄、BMI和HOMA-IR后，尿MG-H1水平与收缩压和舒张压、脉压、平均动脉压以及总胆固醇和低密度脂蛋白胆固醇呈正相关（均P＜0.05）。尿CML水平与心血管参数之间以及尿MG-H1水平与血糖测量值之间均无关联。我们的数据支持尿AGEs在胰岛素抵抗和心血管疾病病理生理学中的作用；然而，未来的研究非常有必要。
