Seremelis Isidoros, Danezis Georgios P, Pappas Athanasios C, Zoidis Evangelos, Fegeros Kostas
Chemistry Laboratory, Department of Food Science and Human Nutrition, Agricultural University of Athens, 75 Iera Odos, 11855 Athens, Greece.
Department of Nutritional Physiology and Feeding, Faculty of Animal Science, Agricultural University of Athens, 75 Iera Odos, 11855 Athens, Greece.
Antioxidants (Basel). 2019 Jul 10;8(7):216. doi: 10.3390/antiox8070216.
Selenium, through incorporation into selenoproteins, is one of the key elements of the antioxidant system. Over the past few years there has been increased interest in exploring those molecular mechanisms in chicken, responsible for the development of this protection system. In more detail, Cd/Pb poisoning and heat stress increase oxidation, mRNA levels of inflammatory proteins, and apoptotic proteins. Selenium seems to enhance the antioxidant status and alleviates these effects via upregulation of antioxidant proteins and other molecular effects. In this review, we analyze avian transcriptome key elements with particular emphasis on interactions with heavy metals and on relation to heat stress.
硒通过掺入硒蛋白，是抗氧化系统的关键元素之一。在过去几年中，人们对探索鸡体内负责这种保护系统发育的分子机制越来越感兴趣。更详细地说，镉/铅中毒和热应激会增加氧化、炎症蛋白的mRNA水平和凋亡蛋白。硒似乎可以增强抗氧化状态，并通过上调抗氧化蛋白和其他分子效应来减轻这些影响。在这篇综述中，我们分析了禽类转录组的关键元素，特别强调了与重金属的相互作用以及与热应激的关系。
