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用于减少癌症干细胞的多功能白蛋白稳定金纳米簇

Multifunctional Albumin-Stabilized Gold Nanoclusters for the Reduction of Cancer Stem Cells.

作者信息

Latorre Ana, Latorre Alfonso, Castellanos Milagros, Rodriguez Diaz Ciro, Lazaro-Carrillo Ana, Aguado Tania, Lecea Mercedes, Romero-Pérez Sonia, Calero Macarena, Sanchez-Puelles José María, Villanueva Ángeles, Somoza Álvaro

机构信息

Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA Nanociencia) & Nanobiotecnología (IMDEA-Nanociencia), Unidad Asociada al Centro Nacional de Biotecnología (CSIC), 28049 Madrid, Spain.

Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid, Spain.

出版信息

Cancers (Basel). 2019 Jul 10;11(7):969. doi: 10.3390/cancers11070969.

DOI:10.3390/cancers11070969
PMID:31295963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6678462/
Abstract

Controlled delivery of multiple chemotherapeutics can improve the effectiveness of treatments and reduce side effects and relapses. Here in, we used albumin-stabilized gold nanoclusters modified with doxorubicin and SN38 (AuNCs-DS) as combined therapy for cancer. The chemotherapeutics are conjugated to the nanostructures using linkers that release them when exposed to different internal stimuli (Glutathione and pH). This system has shown potent antitumor activity against breast and pancreatic cancer cells. Our studies indicate that the antineoplastic activity observed may be related to the reinforced DNA damage generated by the combination of the drugs. Moreover, this system presented antineoplastic activity against mammospheres, a culturing model for cancer stem cells, leading to an efficient reduction of the number of oncospheres and their size. In summary, the nanostructures reported here are promising carriers for combination therapy against cancer and particularly to cancer stem cells.

摘要

多种化疗药物的可控递送可以提高治疗效果，减少副作用和复发。在此，我们使用用阿霉素和SN38修饰的白蛋白稳定金纳米簇（AuNCs-DS）作为癌症联合治疗药物。化疗药物通过连接子与纳米结构结合，当暴露于不同的内部刺激（谷胱甘肽和pH值）时，连接子会释放药物。该系统已显示出对乳腺癌和胰腺癌细胞的强大抗肿瘤活性。我们的研究表明，观察到的抗肿瘤活性可能与药物组合产生的增强的DNA损伤有关。此外，该系统对癌球（一种癌症干细胞培养模型）具有抗肿瘤活性，导致癌球数量及其大小有效减少。总之，本文报道的纳米结构是用于癌症联合治疗尤其是针对癌症干细胞的有前景的载体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d14/6678462/0e4c2f7ed7ec/cancers-11-00969-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d14/6678462/235f3feb0107/cancers-11-00969-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d14/6678462/107484f304d9/cancers-11-00969-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d14/6678462/e47096801c3a/cancers-11-00969-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d14/6678462/e51a38186bc2/cancers-11-00969-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d14/6678462/10549ae32c67/cancers-11-00969-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d14/6678462/616bdc17af66/cancers-11-00969-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d14/6678462/354dd7dafaca/cancers-11-00969-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d14/6678462/d4deed6767f7/cancers-11-00969-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d14/6678462/0e4c2f7ed7ec/cancers-11-00969-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d14/6678462/235f3feb0107/cancers-11-00969-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d14/6678462/107484f304d9/cancers-11-00969-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d14/6678462/e47096801c3a/cancers-11-00969-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d14/6678462/e51a38186bc2/cancers-11-00969-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d14/6678462/10549ae32c67/cancers-11-00969-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d14/6678462/616bdc17af66/cancers-11-00969-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d14/6678462/354dd7dafaca/cancers-11-00969-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d14/6678462/d4deed6767f7/cancers-11-00969-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d14/6678462/0e4c2f7ed7ec/cancers-11-00969-g009.jpg

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