Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Science. 2019 Jul 12;365(6449). doi: 10.1126/science.aau4735.
Characterizing the organization of the human gut microbiota is a formidable challenge given the number of possible interactions between its components. Using a statistical approach initially applied to financial markets, we measured temporally conserved covariance among bacterial taxa in the microbiota of healthy members of a Bangladeshi birth cohort sampled from 1 to 60 months of age. The results revealed an "ecogroup" of 15 covarying bacterial taxa that provide a concise description of microbiota development in healthy children from this and other low-income countries, and a means for monitoring community repair in undernourished children treated with therapeutic foods. Features of ecogroup population dynamics were recapitulated in gnotobiotic piglets as they transitioned from exclusive milk feeding to a fully weaned state consuming a representative Bangladeshi diet.
鉴于人类肠道微生物组中各个组成部分之间可能存在大量的相互作用，因此对其进行组织描述是一项艰巨的挑战。我们采用一种最初应用于金融市场的统计方法，测量了在孟加拉国一个出生队列中健康成员的微生物组中细菌分类群之间随时间变化的协方差，该队列的样本采集时间为 1 至 60 个月。结果揭示了一个由 15 个协变细菌分类群组成的“生态群”，该生态群为来自该队列和其他低收入国家的健康儿童的微生物组发展提供了一个简洁的描述，也为监测接受治疗性食品的营养不良儿童的社区修复提供了一种方法。在从单纯的牛奶喂养过渡到完全断奶并摄入具有代表性的孟加拉国饮食的过程中，无菌仔猪的生态群种群动态特征得到了再现。
