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探究知觉在恐惧泛化中的作用。

Probing the role of perception in fear generalization.

机构信息

Center for the Psychology of Learning and Experimental Psychopathology, Faculty of Psychology and Educational Sciences, KU Leuven, Tiensestraat 102, Box 3712, 3000, Leuven, Belgium.

Health Psychology, Faculty of Psychology and Educational Sciences, KU Leuven, Tiensestraat 102, Box 3726, 3000, Leuven, Belgium.

出版信息

Sci Rep. 2019 Jul 11;9(1):10026. doi: 10.1038/s41598-019-46176-x.

DOI:10.1038/s41598-019-46176-x
PMID:31296943
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6624264/
Abstract

Behavior in novel situations is guided by similarities to previous experiences, a phenomenon known as generalization. Despite the widespread influence of generalization on healthy and pathological behavior, insight into the underlying mechanisms is lacking. It remains unclear whether a failure to notice situational changes contributes to the generalization of learned behavior. We combined a fear conditioning and generalization procedure with a perceptual decision task in humans and found that a failure to perceive a novel stimulus as different from the initial fear-evoking stimulus was associated with increased conditioned responding. These findings demonstrate the potential of a perception-centered approach to better understand (pathological) behavior and its underlying mechanism and are a promising avenue for the development of refined generalization protocols.

摘要

在新情境中的行为受先前经验相似性的指导,这一现象被称为泛化。尽管泛化对健康和病态行为有着广泛的影响,但对其潜在机制仍缺乏了解。目前尚不清楚未能注意到情境变化是否会导致所学行为的泛化。我们在人类中结合了恐惧条件反射和泛化程序与知觉决策任务,发现未能将新刺激感知为与最初引起恐惧的刺激不同与增强的条件反应有关。这些发现表明,一种以感知为中心的方法具有潜在的优势,可以更好地理解(病态)行为及其潜在机制,并且是开发更精细的泛化协议的有前途的途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb32/6624264/3e4c76fa8814/41598_2019_46176_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb32/6624264/570476f87230/41598_2019_46176_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb32/6624264/2e64a733c1e4/41598_2019_46176_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb32/6624264/be6b4bcc66ca/41598_2019_46176_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb32/6624264/3e4c76fa8814/41598_2019_46176_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb32/6624264/570476f87230/41598_2019_46176_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb32/6624264/2e64a733c1e4/41598_2019_46176_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb32/6624264/be6b4bcc66ca/41598_2019_46176_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb32/6624264/3e4c76fa8814/41598_2019_46176_Fig4_HTML.jpg

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本文引用的文献

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Behav Res Ther. 2019 Mar;114:44-50. doi: 10.1016/j.brat.2019.01.006. Epub 2019 Jan 18.
2
The influence of acoustic startle probes on fear learning in humans.声惊探头对人类恐惧学习的影响。
Sci Rep. 2018 Sep 28;8(1):14552. doi: 10.1038/s41598-018-32646-1.
3
Gradients of fear: How perception influences fear generalization.恐惧梯度:感知如何影响恐惧泛化。
NPJ Sci Learn. 2024 Dec 19;9(1):78. doi: 10.1038/s41539-024-00287-x.
4
Anticipated variability increases generalization of predictive learning.预期的变异性会增强预测性学习的泛化能力。
NPJ Sci Learn. 2024 Sep 7;9(1):55. doi: 10.1038/s41539-024-00269-z.
5
Humans display interindividual differences in the latent mechanisms underlying fear generalization behaviour.人类在恐惧泛化行为背后的潜在机制上表现出个体差异。
Commun Psychol. 2023 Aug 1;1(1):5. doi: 10.1038/s44271-023-00005-0.
6
Acute stress leaves fear generalization in healthy individuals intact.急性应激使健康个体的恐惧泛化保持完整。
Cogn Affect Behav Neurosci. 2021 Apr;21(2):372-389. doi: 10.3758/s13415-021-00874-0. Epub 2021 Feb 24.
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Stimulus-Based Extinction Generalization: Neural Correlates and Modulation by Cortisol.基于刺激的消退泛化:神经相关性和皮质醇的调制。
Int J Neuropsychopharmacol. 2021 Apr 21;24(4):354-365. doi: 10.1093/ijnp/pyaa085.
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9
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Neurosci Biobehav Rev. 2015 Dec;59:201-7. doi: 10.1016/j.neubiorev.2015.11.004. Epub 2015 Nov 10.
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Fear Generalization and Anxiety: Behavioral and Neural Mechanisms.恐惧泛化与焦虑:行为与神经机制。
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