Gupta Aditya K, Stec Nadia
Division of Dermatology, Department of Medicine, University of Toronto School of Medicine, Toronto, Canada.
Mediprobe Research Inc., London, Ontario, Canada.
F1000Res. 2019 Jun 25;8. doi: 10.12688/f1000research.18646.1. eCollection 2019.
Onychomycosis is the most common affliction of the nail. It may be caused by dermatophytes, yeasts, and non-dermatophyte molds. Traditionally, oral antifungal treatments have been used to treat the fungus, although they can be accompanied by side effects and drug interactions. Topical treatments provide an alternative modality, bypassing the systemic effects of oral drugs; recent research has centered on topical drug improvement and development. Physical and laser treatments are being used in conjunction with topicals, which may help penetrate the thick nail plate. In this review, techniques from all categories are outlined: both novel experimental approaches and progress and effectiveness of recently developed treatments. More long-term studies are required to determine the efficacy of various treatments, but cure rates are improved when patients adhere to treatments and follow preventative measures to avoid disease recurrence.
甲癣是最常见的指甲疾病。它可能由皮肤癣菌、酵母菌和非皮肤癣菌霉菌引起。传统上，口服抗真菌药物用于治疗这种真菌，尽管它们可能伴有副作用和药物相互作用。局部治疗提供了一种替代方式，避免了口服药物的全身作用；最近的研究集中在局部药物的改进和开发上。物理和激光治疗正与局部治疗联合使用，这可能有助于穿透厚厚的甲板。在这篇综述中，概述了所有类别的技术：包括新颖的实验方法以及最近开发的治疗方法的进展和有效性。需要更多的长期研究来确定各种治疗方法的疗效，但当患者坚持治疗并采取预防措施以避免疾病复发时，治愈率会提高。
