Bitew Adane, Osman Feruza, Yassin Seid
Department of Medical Laboratory Science, College Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Saint Peter's Specialized Tuberculosis Referral Hospital, Addis Ababa, Addis Ababa Administrative Region, Ethiopia.
Clin Cosmet Investig Dermatol. 2022 Mar 23;15:507-518. doi: 10.2147/CCID.S357738. eCollection 2022.
Onychomycosis is a common refractory fungal infection associated with significant morbidity. The objective of this study was to determine the prevalence of onychomycosis, and the diversity and species composition of fungal etiological agents.
A clinic-based, prospective, non-randomized cross-sectional study was carried out between October 2018 and June 2019 at Rank Higher Specialized Dermatology Clinic, Addis Ababa, Ethiopia. Nail scrapings were collected aseptically from 200 patients clinically identified with nail disorders of fungal origin by dermatologists. Fungal etiological agents were identified microscopically and by culture method following standard procedures.
Among 200 nail scrapings, 161 (80.5%) samples were found out to be culture positive. Of these, 135 (83.9%) samples yielded single colonies while 26 (16.1%) mixed colonies gave a total of 190 isolates. Among the isolates, 25.8% were dermatophytes while 61.1% were non- dermatophytes molds, and 13.1% were yeasts. Females were more likely to present dystrophic nails than men. Patients in the middle age group were more affected. spp, and were the dominant species.
The prevalence rate of onychomycosis in the present study was high. The isolation rate of non-dermatophyte molds was higher than dermatophytes and yeasts. spp, and were the dominant etiological agents. Females and patients in the middle age group were more affected. An increase in the prevalence of non-dermatophyte molds in nail infections dictates further investigation demonstrating how this group of fungi causes onychomycosis.
甲癣是一种常见的难治性真菌感染，会引发严重疾病。本研究的目的是确定甲癣的患病率以及真菌病原体的多样性和种类构成。
2018年10月至2019年6月，在埃塞俄比亚亚的斯亚贝巴的兰克高级专科皮肤科诊所开展了一项基于临床的前瞻性非随机横断面研究。皮肤科医生从200名临床诊断为真菌性甲病的患者中无菌采集指甲碎屑。按照标准程序，通过显微镜检查和培养方法鉴定真菌病原体。
在200份指甲碎屑样本中，161份（80.5%）样本培养呈阳性。其中，135份（83.9%）样本长出单菌落，26份（16.1%）混合菌落共产生190株分离株。在这些分离株中，25.8%为皮肤癣菌，61.1%为非皮肤癣菌霉菌，13.1%为酵母菌。女性比男性更易出现甲营养不良。中年组患者受影响更大。[此处原文缺失具体菌种名称]是优势菌种。
本研究中甲癣的患病率较高。非皮肤癣菌霉菌的分离率高于皮肤癣菌和酵母菌。[此处原文缺失具体菌种名称]是主要病原体。女性和中年组患者受影响更大。指甲感染中非皮肤癣菌霉菌患病率的增加表明需要进一步研究以证实这类真菌如何引发甲癣。
