交沙霉素、螺旋霉素和红霉素对立氏立克次体和康氏立克次体的体外评价
In vitro evaluation of josamycin, spiramycin, and erythromycin against Rickettsia rickettsii and R. conorii.
作者信息
Raoult D, Roussellier P, Tamalet J
机构信息
Centre National de Référence des Rickettsioses, CHU La Timone, Marseille, France.
出版信息
Antimicrob Agents Chemother. 1988 Feb;32(2):255-6. doi: 10.1128/AAC.32.2.255.
Abstract
The antimicrobial activities of josamycin, erythromycin, and spiramycin against Rickettsia conorii and R. rickettsii were evaluated in two tests: a dye-uptake assay and a plaque assay. The MIC of josamycin was 1 microgram/ml for both species; the MICs of erythromycin and spiramycin were 4 to 8 and 16 to 32 micrograms/ml, respectively, for both species. Only josamycin may be of clinical use in treating spotted fever rickettsiosis. It may be useful in treating pregnant women and young children.
摘要
在两项试验中评估了交沙霉素、红霉素和螺旋霉素对康氏立克次体和立氏立克次体的抗菌活性：染料摄取试验和平板试验。交沙霉素对这两种菌的最低抑菌浓度（MIC）均为1微克/毫升；红霉素和螺旋霉素对这两种菌的MIC分别为4至8微克/毫升和16至32微克/毫升。只有交沙霉素可能在治疗斑点热立克次体病方面有临床应用价值。它可能对治疗孕妇和幼儿有用。
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