立氏立克次体和康氏立克次体对罗红霉素和普那霉素的体外敏感性
In vitro susceptibilities of Rickettsia rickettsii and Rickettsia conorii to roxithromycin and pristinamycin.
作者信息
Drancourt M, Raoult D
机构信息
Centre National de Référence des Rickettsioses, Centre Hospitalier Universitaire Timone, Marseille, France.
出版信息
Antimicrob Agents Chemother. 1989 Dec;33(12):2146-8. doi: 10.1128/AAC.33.12.2146.
Abstract
In vitro susceptibilities of Rickettsia rickettsii and Rickettsia conorii to roxithromycin, pristinamycin, and the pristinamycin compounds, P1 and P2, were determined by a dye uptake assay and a plaque assay. The MICs were 1 microgram/ml for roxithromycin, 2 micrograms/ml for pristinamycin, greater than 256 micrograms/ml for P1, and 2 micrograms/ml for P2. Compounds P1 and P2 did not share synergetic activity. The toxicity of each compound was determined by a dye uptake assay. Toxic concentrations were 128 micrograms/ml for roxithromycin, 32 micrograms/ml for pristinamycin, greater than 256 micrograms/ml for P1, and 32 micrograms/ml for P2. Roxithromycin and pristinamycin could be useful in the treatment of Rocky Mountain spotted fever and Mediterranean spotted fever.
摘要
通过染料摄取试验和平板试验测定了立氏立克次体和康氏立克次体对罗红霉素、 pristinamycin以及pristinamycin化合物P1和P2的体外敏感性。罗红霉素的最低抑菌浓度（MIC）为1微克/毫升，pristinamycin为2微克/毫升，P1大于256微克/毫升，P2为2微克/毫升。化合物P1和P2没有协同活性。通过染料摄取试验测定了每种化合物的毒性。罗红霉素的毒性浓度为128微克/毫升，pristinamycin为32微克/毫升，P1大于256微克/毫升，P2为32微克/毫升。罗红霉素和pristinamycin可用于治疗落基山斑疹热和地中海斑疹热。
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