Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Environmental Health Investigations Branch, California Dept. of Public Health, Richmond, CA, USA.
Int J Hyg Environ Health. 2019 Aug;222(7):1038-1046. doi: 10.1016/j.ijheh.2019.07.002. Epub 2019 Jul 9.
We conducted a study of per- and polyfluoroalkyl substance biomarkers, including PFOA, in girls from Greater Cincinnati (CIN, N = 353) and the San Francisco Bay Area (SFBA, N = 351). PFOA was measured in the baseline serum sample collected in 2004-2007 of 704 girls at age 6-8 years. Mixed effects models were used to derive the effect of PFOA on BMI, waist-to-height and waist-to-hip ratios over increasing age in this longitudinal cohort.
Median PFOA serum concentrations were 7.3 (CIN) and 5.8 (SFBA) ng/mL, above the U.S. population median for children 12-19 years in 2005-2006 (3.8 ng/mL). Log-transformed serum PFOA had a strong inverse association with BMIz in the CIN girls (p = 0.0002) and the combined two-site data (p = 0.0008); the joint inverse effect of PFOA and Age*PFOA weakened at age at 10-11 years. However, in the SFBA group alone, the relationship was not significant (p = 0.1641) with no evidence of changing effect with age. The effect of PFOA on waist:height ratio was similar to BMIz at both sites, but we did not find a significant effect of PFOA on waist:hip ratio in either the CIN or SFBA girls.
PFOA is associated with decreased BMI and waist:height ratio in young girls, but the strength of the relationship decreases with age. Site heterogeneity may be due to greater early life exposure in Cincinnati.
The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. Use of trade names is for identification only and does not imply endorsement by the CDC, the Public Health Service, or the US Department of Health and Human Services.
我们进行了一项关于全氟和多氟烷基物质生物标志物（包括 PFOA）的研究，研究对象为辛辛那提（CIN，N=353）和旧金山湾区（SFBA，N=351）的女孩。在 2004-2007 年，我们对 704 名 6-8 岁女孩的基线血清样本进行了 PFOA 测量。在这个纵向队列中，我们使用混合效应模型来推导 PFOA 对 BMI、腰围-身高比和腰围-臀围比随年龄增长的影响。
CIN 女孩的血清 PFOA 中位数浓度为 7.3（CIN）和 5.8（SFBA）ng/mL，高于 2005-2006 年美国 12-19 岁儿童的人群中位数（3.8 ng/mL）。CIN 女孩的血清 PFOA 经对数转换后与 BMIz 呈强烈负相关（p=0.0002），与两地合并数据也呈负相关（p=0.0008）；PFOA 和年龄*PFOA 的联合负效应在 10-11 岁时减弱。然而，在 SFBA 组中，这种关系并不显著（p=0.1641），且没有证据表明其随年龄而变化。PFOA 对腰高比的影响与两个部位的 BMIz 相似，但我们没有发现 PFOA 对 CIN 或 SFBA 女孩的腰臀比有显著影响。
PFOA 与年轻女孩的 BMI 和腰高比降低有关，但这种关系的强度随年龄增长而减弱。地点差异可能是由于辛辛那提的早期生活暴露更大。
本报告中的发现和结论仅代表作者的观点，不一定代表疾病预防控制中心的官方立场。使用商标仅用于识别，并不表示疾病预防控制中心、公共卫生服务机构或美国卫生与公众服务部的认可。
