Rajitha Balney, Malla Rama Rao, Vadde Ramakrishna, Kasa Prameswari, Prasad Ganji Lakshmi Vara, Farran Batoul, Kumari Seema, Pavitra Eluri, Kamal Mohammad Amjad, Raju Ganji Seeta Rama, Peela Sujatha, Nagaraju Ganji Purnachandra
Department of Pathology, WellStar Hospital, Marietta, GA, 30060, USA.
Department of Biochemistry, GITAM Institute of Science, GITAM University, Visakhapatnam, AP, 530045, India.
Semin Cancer Biol. 2021 Feb;69:376-390. doi: 10.1016/j.semcancer.2019.07.005. Epub 2019 Jul 10.
Female-specific cancers are the most common cancers in women worldwide. Early detection methods remain unavailable for most of these cancers, signifying that most of them are diagnosed at later stages. Furthermore, current treatment options for most female-specific cancers are surgery, radiation and chemotherapy. Although important milestones in molecularly targeted approaches have been achieved lately, current therapeutic strategies for female-specific cancers remain limited, ineffective and plagued by the emergence of chemoresistance, which aggravates prognosis. Recently, the application of nanotechnology to the medical field has allowed the development of novel nano-based approaches for the management and treatment of cancers, including female-specific cancers. These approaches promise to improve patient survival rates by reducing side effects, enabling selective delivery of drugs to tumor tissues and enhancing the uptake of therapeutic compounds, thus increasing anti-tumor activity. In this review, we focus on the application of nano-based technologies to the design of novel and innovative diagnostic and therapeutic strategies in the context of female-specific cancers, highlighting their potential uses and limitations.
女性特异性癌症是全球女性中最常见的癌症。大多数这类癌症仍缺乏早期检测方法，这意味着大多数患者在疾病晚期才被诊断出来。此外，目前针对大多数女性特异性癌症的治疗选择是手术、放疗和化疗。尽管最近在分子靶向治疗方面取得了重要进展，但目前针对女性特异性癌症的治疗策略仍然有限、效果不佳，并且受到化疗耐药性出现的困扰，这使得预后恶化。最近，纳米技术在医学领域的应用推动了新型纳米技术在癌症（包括女性特异性癌症）管理和治疗方面的发展。这些方法有望通过减少副作用、实现药物向肿瘤组织的选择性递送以及增强治疗性化合物的摄取来提高患者生存率，从而增强抗肿瘤活性。在本综述中，我们重点关注基于纳米技术在女性特异性癌症背景下设计新型创新诊断和治疗策略的应用，突出其潜在用途和局限性。
