RNA 及 RNA 相关蛋白在调控 DNA 双链断裂修复途径选择中的作用。
The role of RNA and RNA-related proteins in the regulation of DNA double strand break repair pathway choice.
机构信息
Departamento de Genética, Universidad de Sevilla, Sevilla, 41080, Spain; Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Sevilla, 41092, Spain.
Departamento de Genética, Universidad de Sevilla, Sevilla, 41080, Spain; Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Sevilla, 41092, Spain.
出版信息
DNA Repair (Amst). 2019 Sep;81:102662. doi: 10.1016/j.dnarep.2019.102662. Epub 2019 Jul 8.
DNA end resection is a critical step in the repair of DNA double strand breaks. It controls the way the lesion is going to be repaired, thus its regulation has a great importance in maintaining genomic stability. In this review, we focus in recent discoveries in the field that point to a modulation of resection by RNA molecules and RNA-related proteins. Moreover, we aim to reconcile contradictory reports on the positive or negative effect of DNA:RNA hybrids in the resection process.
DNA 末端切除是修复 DNA 双链断裂的关键步骤。它控制着损伤的修复方式，因此其调控对于维持基因组稳定性具有重要意义。在这篇综述中，我们重点介绍了该领域的最新发现，这些发现指出了 RNA 分子和 RNA 相关蛋白对切除的调节作用。此外，我们还旨在调和 DNA:RNA 杂合体在切除过程中产生正向或负向影响的相互矛盾的报告。
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