Jimeno Sonia, Balestra Fernando R, Huertas Pablo
Departamento de Genética, Universidad de Sevilla, Seville, Spain.
Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.
Front Mol Biosci. 2021 Apr 29;8:664872. doi: 10.3389/fmolb.2021.664872. eCollection 2021.
The correct repair of DNA double-strand breaks is essential for maintaining the stability of the genome, thus ensuring the survival and fitness of any living organism. Indeed, the repair of these lesions is a complicated affair, in which several pathways compete for the DNA ends in a complex balance. Thus, the fine-tuning of the DNA double-strand break repair pathway choice relies on the different regulatory layers that respond to environmental cues. Among those different tiers of regulation, RNA modifications have just emerged as a promising field.
DNA双链断裂的正确修复对于维持基因组的稳定性至关重要，从而确保任何生物体的存活和适应性。事实上，这些损伤的修复是一件复杂的事情，其中几种途径在复杂的平衡中争夺DNA末端。因此，DNA双链断裂修复途径选择的微调依赖于对环境线索做出反应的不同调节层。在这些不同层次的调节中，RNA修饰刚刚成为一个有前景的领域。
