Harlow B L, Hartge P A
Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Havard Medical School, Boston, Massachusetts 02115, USA.
Regul Toxicol Pharmacol. 1995 Apr;21(2):254-60. doi: 10.1006/rtph.1995.1039.
The authors provide a detailed review of the events that led to the interest in talc as a possible ovarian carcinogen, the epidemiological studies published to date, and their perspective on the interpretation of the findings including potential limitations, biases, and issues surrounding the plausibility of a causal association. The authors conclude that the range of relative risk estimates from epidemiology, 1.0 to 1.8, is plausible, but that additional epidemiologic studies, especially prospective investigations are needed. In addition, clinicopathological studies are needed to confirm or deny the reports of talc embedded in human ovarian tissue and reports of talc migration through the human female reproductive tract.
作者详细回顾了引发人们对滑石粉可能成为卵巢致癌物产生兴趣的相关事件、迄今为止发表的流行病学研究，以及他们对研究结果解读的观点，包括潜在的局限性、偏差以及围绕因果关联合理性的问题。作者得出结论，流行病学研究得出的相对风险估计范围为1.0至1.8是合理的，但还需要进行更多的流行病学研究，尤其是前瞻性调查。此外，需要开展临床病理研究，以证实或否定有关人类卵巢组织中嵌入滑石粉以及滑石粉通过人类女性生殖道迁移的报告。
