Jo Eun-Jung, Eom Jung Seop, Mok Jeongha, Kim Mi-Hyun, Lee Kwangha, Kim Ki Uk, Lee Min Ki, Park Hye-Kyung
Department of Internal Medicine, Pusan National University School of Medicine, Busan.
Department of Internal Medicine, Pusan National University Hospital, Busan.
Asian Pac J Allergy Immunol. 2021 Sep;39(3):182-189. doi: 10.12932/AP-261118-0447.
Allergen sensitization and its influence on allergic disease can vary depending on ethnicity and geography.
To investigate aeroallergen sensitization patterns and their effect on airway hyper-responsiveness (AHR) in Busan, Korea.
We reviewed data for subjects who attended for evaluation of respiratory symptoms between 2011 and 2016. The skin test results of 16 allergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat, dog, Alternaria, Aspergillus fumigatus, early blossoming tree pollen mix, late blossoming tree pollen mix, alder, birch, oak, grass mix, mugwort, ragweed, and Japanese hop) were analyzed. Age was categorized as group I (15 to < 65 years) or group II (≥ 65 years).
A total of 2,791 subjects were analyzed (mean age: 50.9 years, female 61.3%). AHR was demonstrated in 15.8%; sputum eosinophilia in 12.1%; and atopy in 31.2%. The most commonly sensitizing allergen was house dust mite (17.4% to D. pteronyssinus and 17.9% to D. farinae), followed by late blossoming tree pollen mix (8.8%) and early blossoming tree pollen mix (8.6%). AHR was associated with sensitization to D. pteronyssinus, D. farina, Alternaria, dog, cat, alder, birch, oak, and mugwort. However, group II did not show any associations between AHR and any of the aeroallergens except D. farina. Multiple logistic regression analyses showed that the independent factors for AHR were ever-smoker status, D. farina, and oak sensitization.
Sensitization to house dust mites and tree pollen was found to be common in Busan. These aeroallergens significantly affected AHR, particularly in the younger group.
变应原致敏及其对过敏性疾病的影响可能因种族和地理位置而异。
调查韩国釜山地区气传变应原致敏模式及其对气道高反应性（AHR）的影响。
我们回顾了2011年至2016年间因呼吸道症状前来评估的受试者的数据。分析了16种变应原（粉尘螨、屋尘螨、猫、狗、链格孢属、烟曲霉、早花树花粉混合物、晚花树花粉混合物、桤木、桦树、橡树、草混合物、艾蒿、豚草和啤酒花）的皮肤试验结果。年龄分为I组（15至<65岁）或II组（≥65岁）。
共分析了2791名受试者（平均年龄：50.9岁，女性占61.3%）。15.8%的受试者表现出气道高反应性；12.1%的受试者痰液嗜酸性粒细胞增多；31.2%的受试者为特应性体质。最常见的致敏变应原是屋尘螨（粉尘螨为17.4%，屋尘螨为17.9%），其次是晚花树花粉混合物（8.8%）和早花树花粉混合物（8.6%）。气道高反应性与对粉尘螨、屋尘螨、链格孢属、狗、猫、桤木、桦树、橡树和艾蒿的致敏有关。然而，II组除屋尘螨外，未显示气道高反应性与任何气传变应原之间存在关联。多因素logistic回归分析显示，气道高反应性的独立因素为曾经吸烟状态、屋尘螨和橡树致敏。
在釜山，对屋尘螨和树花粉的致敏很常见。这些气传变应原显著影响气道高反应性，尤其是在较年轻的人群中。
