Department of Pathogen Biology, Guangdong Provincial Key Laboratory of Tropical Disease Research, Southern Medical University, Guangzhou, Guangdong Province 510515, China.
Department of Anatomy, Histology and Embryology, Shanghai Medical School of Fudan University, Shanghai 200011, China.
Int J Mol Sci. 2019 Jul 15;20(14):3467. doi: 10.3390/ijms20143467.
Hector insect toxin (AaIT), an insect-selective toxin, was identified in the venom of the scorpion . The exclusive and specific target of the toxin is the voltage-gated sodium channels of the insect, resulting in fast excitatory paralysis and even death. Because of its strict toxic selectivity and high bioactivity, AaIT has been widely used in experiments exploring pest bio-control. Recombinant expression of AaIT in a baculovirus or a fungus can increase their virulence to insect pests and diseases vectors. Likewise, transgenic plants expressing AaIT have notable anti-insect activity. AaIT is an efficient toxin and has great potential to be used in the development of commercial insecticides.
赫克托昆虫毒素（AaIT）是一种昆虫选择性毒素，在蝎子的毒液中被发现。该毒素的唯一且特定的靶标是昆虫的电压门控钠离子通道，导致快速兴奋麻痹甚至死亡。由于其严格的毒性选择性和高生物活性，AaIT 已被广泛应用于探索害虫生物防治的实验中。在杆状病毒或真菌中重组表达 AaIT 可以提高其对害虫和疾病媒介的毒力。同样，表达 AaIT 的转基因植物具有显著的抗虫活性。AaIT 是一种高效的毒素，具有很大的潜力可用于开发商业杀虫剂。
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