Wang Haiyang, Peng Hui, Li Wenjuan, Cheng Peng, Gong Maoqing
Shandong Institute of Parasitic Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences, Jining, China.
College of Forensic Medicine and Laboratory Medicine, Jining Medical University, Jining, China.
Front Microbiol. 2021 Aug 26;12:705343. doi: 10.3389/fmicb.2021.705343. eCollection 2021.
The long-term and excessive usage of pesticides is an enormous burden on the environment, which also increases pest resistance. To overcome this problem, research and application of entomopathogenic fungi, which are both environmentally friendly and cause lower resistance, have gained great momentum. Entomopathogenic fungi have a wide range of prospects. Apart from , is the most studied biopesticide. After invading insect hosts, produces a variety of toxins, which are secondary metabolites such as beauvericin, bassianin, bassianolide, beauverolides, tenellin, oosporein, and oxalic acid. These toxins help to parasitize and kill the hosts. This review unequivocally considers beauveria toxins highly promising and summarizes their attack mechanism(s) on the host insect immune system. Genetic engineering strategies to improve toxin principles, genes, or virulent molecules of have also been discussed. Lastly, we discuss the future perspective of toxin research, including newly discovered toxins.
长期过量使用农药给环境带来了巨大负担，同时也增加了害虫的抗药性。为克服这一问题，对环境友好且抗药性较低的昆虫病原真菌的研究与应用得到了大力发展。昆虫病原真菌具有广泛的应用前景。除了 ， 是研究最多的生物农药。侵入昆虫宿主后， 会产生多种毒素，这些毒素是诸如白僵菌素、球孢菌素、球孢醇、白僵菌素类、细交链孢菌酮酸、卵孢霉素和草酸等次生代谢产物。这些毒素有助于 寄生并杀死宿主。本综述明确认为白僵菌毒素极具前景，并总结了它们对宿主昆虫免疫系统的攻击机制。还讨论了改善 毒素原理、基因或毒力分子的基因工程策略。最后，我们讨论了 毒素研究的未来前景，包括新发现的毒素。
