GC-MS & preliminary screening profile of Cordia sinensis leaves - antiglycation, antifungal and insecticidal agents.

Crude extracts and fractions of leaves were subjected to gas chromatography-flame ionisation detection (GC-FID), gas chromatography-mass spectrometry (GC-MS) analyses and preliminary screening for biological potentials using antibacterial, antifungal, phytotoxic, cytotoxic, insecticidal, antileishmanicidal and antiglycation bioassays. Overall thirty-one phytochemicals including three hydrocarbons, seven fatty acids, fifteen fatty acid esters, three terpenes, one each of phytosterol, terpenoid, and polyunsaturated aldehyde were identified. n-Hexadecanoic acid (13.2%), methyl hexadecanoate (9.0%), octadec-9-enoic acid (8.3%) and methyl octadec-9,12,15-trienoate (7.8%) were the main components. Presumably, this is a first report of twenty, thirteen and twenty phytochemicals from , and Boraginaceae, respectively. Moreover, ethyl acetate fraction exhibited significant insecticidal and antifungal activity against and , respectively. Similarly, n-hexane fraction significantly inhibited (77.4%) advanced glycation end products in antiglycation assay. Conclusively, leaves with bioactive metabolites are a potential source for the development of insecticides, fungicides and pharmaceutically active antidiabetic drugs.