Department of Chemistry, Federal Urdu University of Arts, Science & Technology, Karachi, Pakistan.
Department of Chemistry, University of Karachi, Karachi, Pakistan.
Nat Prod Res. 2021 Apr;35(7):1212-1216. doi: 10.1080/14786419.2019.1641809. Epub 2019 Jul 17.
Crude extracts and fractions of leaves were subjected to gas chromatography-flame ionisation detection (GC-FID), gas chromatography-mass spectrometry (GC-MS) analyses and preliminary screening for biological potentials using antibacterial, antifungal, phytotoxic, cytotoxic, insecticidal, antileishmanicidal and antiglycation bioassays. Overall thirty-one phytochemicals including three hydrocarbons, seven fatty acids, fifteen fatty acid esters, three terpenes, one each of phytosterol, terpenoid, and polyunsaturated aldehyde were identified. n-Hexadecanoic acid (13.2%), methyl hexadecanoate (9.0%), octadec-9-enoic acid (8.3%) and methyl octadec-9,12,15-trienoate (7.8%) were the main components. Presumably, this is a first report of twenty, thirteen and twenty phytochemicals from , and Boraginaceae, respectively. Moreover, ethyl acetate fraction exhibited significant insecticidal and antifungal activity against and , respectively. Similarly, n-hexane fraction significantly inhibited (77.4%) advanced glycation end products in antiglycation assay. Conclusively, leaves with bioactive metabolites are a potential source for the development of insecticides, fungicides and pharmaceutically active antidiabetic drugs.
叶的粗提取物和馏分经过气相色谱-火焰离子化检测（GC-FID）、气相色谱-质谱（GC-MS）分析，并通过抗菌、抗真菌、植物毒性、细胞毒性、杀虫、抗利什曼原虫和抗糖化生物测定进行了初步筛选，以评估其生物潜力。总共鉴定出 31 种植物化学物质，包括 3 种碳氢化合物、7 种脂肪酸、15 种脂肪酸酯、3 种萜烯、1 种植物甾醇、1 种萜类化合物和 1 种多不饱和醛。正十六烷酸（13.2%）、十六酸甲酯（9.0%）、十八-9-烯酸（8.3%）和十八-9,12,15-三烯酸甲酯（7.8%）是主要成分。据推测，这是首次从 、 和紫草科中分别鉴定出 20、13 和 20 种植物化学物质的报告。此外，乙酸乙酯馏分对 和 表现出显著的杀虫和抗真菌活性。同样，正己烷馏分在抗糖化测定中显著抑制了 77.4%的晚期糖基化终产物。总之，具有生物活性代谢物的 叶是开发杀虫剂、杀菌剂和具有药用活性的抗糖尿病药物的潜在来源。
