小脑破坏会在证据积累过程中损害工作记忆。

Neuroscience Institute, Princeton University, Princeton, NJ, 08544, USA.

Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA.

Nat Commun. 2019 Jul 16;10(1):3128. doi: 10.1038/s41467-019-11050-x.

To select actions based on sensory evidence, animals must create and manipulate representations of stimulus information in memory. Here we report that during accumulation of somatosensory evidence, optogenetic manipulation of cerebellar Purkinje cells reduces the accuracy of subsequent memory-guided decisions and causes mice to downweight prior information. Behavioral deficits are consistent with the addition of noise and leak to the evidence accumulation process. We conclude that the cerebellum can influence the accurate maintenance of working memory.

为了根据感官证据做出行动选择，动物必须在记忆中创建和操作刺激信息的表示。在这里，我们报告称，在躯体感觉证据积累期间，光遗传学操纵小脑浦肯野细胞会降低随后的记忆引导决策的准确性，并导致小鼠对先前信息的重视程度降低。行为缺陷与证据积累过程中噪声和泄漏的增加一致。我们得出结论，小脑可以影响工作记忆的准确维持。