From Schipslootweg 5 8351 HV, Wapserveen, the Netherlands.
Dermatitis. 2019 Jul/Aug;30(4):243-246. doi: 10.1097/DER.0000000000000471.
Linalool is a fragrance widely used in cosmetics and household products. Until recently, contact allergy to linalool was considered rare because positive patch tests to it were infrequently observed. In recent years, however, it has been demonstrated that exposure of linalool to oxygen (air) results in formation of a number of oxidation products, of which the hydroperoxides have a far stronger sensitizing potency than the pure compound. By routine testing of patients suspected of having contact dermatitis with hydroperoxides of linalool, high frequencies of positive reactions were found, indicating these chemicals are important fragrance allergens. It should be realized, however, that a number of "positive" reactions may well be false-positive, irritant responses.
芳樟醇是一种广泛应用于化妆品和家居产品的香料。直到最近，人们还认为芳樟醇的接触过敏很少见，因为对其进行的阳性斑贴试验很少见。然而，近年来已经证明，芳樟醇暴露于氧气（空气）会导致形成许多氧化产物，其中过氧化物的致敏能力远远强于纯化合物。通过对疑似患有接触性皮炎的患者进行芳樟醇过氧化物的常规测试，发现了很高的阳性反应频率，表明这些化学物质是重要的香料过敏原。然而，应该意识到，许多“阳性”反应很可能是假阳性、刺激性反应。
