Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
Adv Healthc Mater. 2019 Aug;8(16):e1900245. doi: 10.1002/adhm.201900245. Epub 2019 Jul 17.
Synthetic polyester elastomeric constructs have become increasingly important for a range of healthcare applications, due to tunable soft elastic properties that mimic those of human tissues. A number of these constructs require intricate mechanical design to achieve a tunable material with controllable curing. Here, the synthesis and characterization of poly(itaconate-co-citrate-co-octanediol) (PICO) is presented, which exhibits tunable formation of elastomeric networks through radical crosslinking of itaconate in the polymer backbone of viscous polyester gels. Through variation of reaction times and monomer molar composition, materials with modulation of a wide range of elasticity (36-1476 kPa) are generated, indicating the tunability of materials to specific elastomeric constructs. This correlated with measured rapid and controllable gelation times. As a proof of principle, scaffold support for cardiac tissue patches is developed, which presents visible tissue organization and viability with appropriate elastomeric support from PICO materials. These formulations present potential application in a range of healthcare applications with requirement for elastomeric support with controllable, rapid gelation under mild conditions.
合成聚酯弹性体结构由于其具有可调软弹性特性，可模拟人体组织，因此在各种医疗保健应用中变得越来越重要。为了实现具有可控固化的可调材料，许多这些结构都需要复杂的机械设计。在这里，提出了聚（衣康酸-co-柠檬酸-co-辛二醇）（PICO）的合成和表征，其通过粘性聚酯凝胶聚合物主链中衣康酸的自由基交联，表现出弹性体网络的可调形成。通过改变反应时间和单体摩尔组成，生成了具有广泛弹性（36-1476kPa）调制的材料，表明材料可针对特定弹性体结构进行调节。这与测量的快速和可控凝胶时间相关。作为原理验证，开发了用于心脏组织贴片的支架支撑，其具有适当的弹性体支撑的可见组织组织和活力，来自 PICO 材料。这些配方具有在需要在温和条件下具有可控、快速凝胶化的弹性体支撑的各种医疗保健应用中的潜在应用。
