Department of Chemistry , Syracuse University , 111 College Place , Syracuse , New York 13244 , United States.
ACS Nano. 2019 Aug 27;13(8):9292-9297. doi: 10.1021/acsnano.9b03880. Epub 2019 Jul 22.
Self-assembly enables formation of incredibly diverse supramolecular structures with practically important functions from simple and inexpensive building blocks. Here, we show how a semirational, bottom-up approach to create emerging properties can be extended to a design of highly enantioselective catalytic nanoassemblies. The designed peptides comprising as few as two amino acid residues spontaneously self-assemble in the presence of metal ions to form supramolecular, vesicle-like nanoassemblies that promote transfer hydrogenation of ketones in an aqueous phase with excellent conversion rates and enantioselectivities (>90% ee).
自组装能够使简单且廉价的构建块形成具有实际重要功能的、种类繁多的超分子结构。在这里，我们展示了如何将一种半理性的、自下而上的方法用于创造新兴性质，扩展到设计高度对映选择性的催化纳米组装体。所设计的肽仅由两个氨基酸残基组成，在金属离子存在的情况下自发组装，形成超分子、囊泡样的纳米组装体，在水相中促进酮的转移氢化，具有极好的转化率和对映选择性（>90%ee）。
