Vicens Laia, Costas Miquel
Institut de Química Computacional i Catàlisi (IQCC) and Departament de Química, Universitat de Girona, Campus Montilivi, Girona E-17071, Catalonia, Spain.
Dalton Trans. 2018 Feb 6;47(6):1755-1763. doi: 10.1039/c7dt03657d.
The stereoselective oxidation of hydrocarbons is one of the most challenging reactions for synthetic chemists. However, this transformation is one of the most common reactions in nature. Metalloenzymes that catalyze this transformation are taken as inspiration for the development of new catalysts. There are several examples in the literature where either peptides or metal catalysts are used in the stereoselective oxidation reaction, but the synergistic combination of both systems is still a non-explored field. The use of metallopeptides in biologically inspired oxidation reactions is discussed in this perspective.
碳氢化合物的立体选择性氧化是合成化学家面临的最具挑战性的反应之一。然而，这种转化是自然界中最常见的反应之一。催化这种转化的金属酶为新型催化剂的开发提供了灵感。文献中有几个例子，其中肽或金属催化剂被用于立体选择性氧化反应，但这两种体系的协同组合仍是一个未被探索的领域。本文从这个角度讨论了金属肽在受生物启发的氧化反应中的应用。
