Amaechi Bennett T, Kasundra Hariyali, Okoye Linda O, Tran Phat L, Reid Ted W
Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Department of Restorative Dentistry, Faculty of Dentistry, College of Medicine, University of Nigeria Teaching Hospital, Ituku Ozalla, Enugu State, Nigeria, Phone: +234 8068424848, e-mail:
J Contemp Dent Pract. 2019 May 1;20(5):531-536.
The purpose of this study is to compare the clinical performance of an organo-selenium-containing pit and fissure sealant with that of a selenium-free sealant for clinical retention and prevention of plaque and caries development around the sealants.
Following an study confirming the antimicrobial effect of an organo-selenium-containing pit/fissure sealant [DenteShield™ (DS)], 120 adolescents (7-20 years old) at varying caries risk status had DS sealant applied to a single tooth on the left or the right side of the dentition and UltraSeal™ XT Plus (UXT) on a corresponding tooth on the opposite side. Sealants' assessment was performed quarterly for 1 year for clinical retention, plaque, and caries formation around the sealant. Each sealant lost was replaced but considered as a failure in further analysis. McNemar's test was used to statistically analyze the outcome variables at each assessment time point.
While 7% and 12% plaque growth was observed around the UXT sealant at 9th and 12th months, respectively, DS exhibited 100% prevention of plaque growth. Both sealants exhibited 100% caries prevention. Clinical retention did not significantly differ between DS and UXT at all assessment time points except at 12 months when DS showed statistically significantly ( < 0.001) better retention (96%) than UXT (81%).
In this study, while both sealants are equally effective in caries prevention, DS completely prevented plaque growth around it with better clinical retention than UXT that offered only limited protection against plaque growth.
Being antimicrobial, DS pit and fissure sealant may be the best sealant option for patients whose caries risk status is due to poor oral hygiene.
本研究旨在比较含有机硒的窝沟封闭剂与不含硒的封闭剂在临床保留率以及预防封闭剂周围菌斑和龋齿发展方面的临床表现。
在一项研究证实含有机硒的窝沟封闭剂[DenteShield™（DS）]具有抗菌作用之后，120名处于不同龋齿风险状态的青少年（7至20岁），在其牙列左侧或右侧的一颗牙齿上应用DS封闭剂，在对侧相应牙齿上应用UltraSeal™ XT Plus（UXT）封闭剂。对封闭剂进行为期1年的季度评估，以观察临床保留情况、封闭剂周围的菌斑和龋齿形成情况。每次封闭剂脱落都进行更换，但在进一步分析中视为失败。使用McNemar检验对每个评估时间点的结果变量进行统计分析。
在第9个月和第12个月时，分别观察到UXT封闭剂周围有7%和12%的菌斑生长，而DS封闭剂对菌斑生长的预防率为100%。两种封闭剂对龋齿的预防率均为100%。除了在12个月时DS的临床保留率（96%）在统计学上显著优于UXT（81%）（<0.001）外，在所有评估时间点，DS和UXT的临床保留率没有显著差异。
在本研究中，虽然两种封闭剂在预防龋齿方面同样有效，但DS能完全防止其周围的菌斑生长，且临床保留率优于UXT，UXT对菌斑生长仅提供有限的保护。
作为具有抗菌作用的DS窝沟封闭剂，对于因口腔卫生差而处于龋齿风险状态的患者可能是最佳的封闭剂选择。
