Yao Chun, Yu Bin
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Front Mol Neurosci. 2019 Jun 28;12:165. doi: 10.3389/fnmol.2019.00165. eCollection 2019.
Nerve injuries may cause severe disability and affect the quality of life. It is of great importance to get a full understanding of the biological processes and molecular mechanisms underlying nerve injuries to find and target specific molecules for nerve regeneration. Numerous studies have shown that noncoding RNAs (ncRNAs) participate in diverse biological processes and diseases. Long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) are two major groups of ncRNAs, which attract growing attention. The altered expression patterns of lncRNAs and circRNAs following nerve injury suggest that these ncRNAs might be associated with nerve regeneration. This review will give a brief introduction of lncRNAs and circRNAs. We then summarize the current studies on lncRNAs and circRNAs following peripheral nerve injury and spinal cord injury (SCI). Typical lncRNAs and circRNAs are introduced to illustrate the diverse molecular mechanisms for nerve regeneration. In addition, we also discuss some issues to be addressed in future investigations on lncRNAs and circRNAs.
神经损伤可能导致严重残疾并影响生活质量。全面了解神经损伤背后的生物学过程和分子机制，以寻找并靶向特定分子促进神经再生，这一点至关重要。大量研究表明，非编码RNA（ncRNA）参与多种生物学过程和疾病。长链非编码RNA（lncRNA）和环状RNA（circRNA）是ncRNA的两大主要类型，它们越来越受到关注。神经损伤后lncRNA和circRNA的表达模式改变表明，这些ncRNA可能与神经再生有关。本综述将简要介绍lncRNA和circRNA。然后我们总结了目前关于周围神经损伤和脊髓损伤（SCI）后lncRNA和circRNA的研究。引入典型的lncRNA和circRNA以阐明神经再生的多种分子机制。此外，我们还讨论了未来lncRNA和circRNA研究中有待解决的一些问题。
