Novotný Michal, Klimova Blanka, Valis Martin
Biomedical Research Centrum, University Hospital Hradec Kralove, Hradec Kralove, Czechia.
Department of Management, Faculty of Informatics and Management, University of Hradec Kralove, Hradec Kralove, Czechia.
Front Aging Neurosci. 2019 Jun 28;11:170. doi: 10.3389/fnagi.2019.00170. eCollection 2019.
The aim of this review is to summarize the effect of human intestinal microbiome on cognitive impairments and to focus primarily on the impact of diet and eating habits on learning processes. Better understanding of the microbiome could revolutionize the possibilities of therapy for many diseases. The authors performed a literature review of available studies on the research topic describing the influence of human microbiome and diet on cognitive impairment or learning processes found in the world's acknowledged databases Web of Science, PubMed, Springer, and Scopus. The digestive tube is populated by billions of living microorganisms including viruses, bacteria, protozoa, helminths, and microscopic fungi. In adulthood, under physiological conditions, the intestinal microbiome appears to be relatively steady. However, it is not true that it would not be influenced, both in the positive sense of the word and in the negative one. The basic pillars that maintain a steady microbiome are genetics, lifestyle, diet and eating habits, geography, and age. It is reported that the gastrointestinal tract and the brain communicate with each other through several pathways and one can speak about gut-brain axis. New evidence is published every year about the association of intestinal dysbiosis and neurological/psychiatric diseases. On the other hand, specific diets and eating habits can have a positive effect on a balanced microbiota composition and thus contribute to the enhancement of cognitive functions, which are important for any learning process.
本综述的目的是总结人类肠道微生物群对认知障碍的影响,并主要关注饮食和饮食习惯对学习过程的影响。更好地了解微生物群可能会彻底改变许多疾病的治疗可能性。作者对世界公认的数据库Web of Science、PubMed、Springer和Scopus中关于人类微生物群和饮食对认知障碍或学习过程影响的现有研究进行了文献综述。消化道中存在着数十亿种活微生物,包括病毒、细菌、原生动物、蠕虫和微小真菌。在成年期,在生理条件下,肠道微生物群似乎相对稳定。然而,它并非不受影响,无论是从积极意义还是消极意义上来说。维持稳定微生物群的基本支柱是遗传学、生活方式、饮食和饮食习惯、地理位置和年龄。据报道,胃肠道和大脑通过多种途径相互沟通,可以说是存在肠脑轴。每年都会有关于肠道菌群失调与神经/精神疾病关联的新证据发表。另一方面,特定的饮食和饮食习惯可以对平衡的微生物群组成产生积极影响,从而有助于增强认知功能,而认知功能对任何学习过程都很重要。