Chen Qiliang, Zhang Yuanyuan, Li Shunan, Chen Shujiao, Lin Xuejuan, Li Candong, Asakawa Tetsuya
Research Base of Traditional Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Department of Neurosurgery, Hamamatsu University School of Medicine, Handayama, Hamamatsu-City, Shizuoka, Japan.
Evid Based Complement Alternat Med. 2019 Jun 17;2019:2536452. doi: 10.1155/2019/2536452. eCollection 2019.
Cholelithiasis is a major public health concern that necessitates highly effective, feasible, and recurrence-preventing therapies. Currently available surgical treatments and medications cannot effectively avoid the recurrence of cholelithiasis. Hence, several Chinese herbal compounds (CHCs) are considered for the treatment of cholelithiasis, considering that they can effectively discharge gallstones and prevent the recurrence of such condition. In the present narrative review, we aim to summarize the underlying mechanisms of currently used CHCs in the treatment of cholelithiasis and to describe the current situation of traditional Chinese medicine (TCM) use for cholelithiasis. Several commonly used CHCs were used to illustrate these issues. We found that the mechanisms underlying the CHC treatments rely on the amelioration of the biliary dynamics factors, maintenance and protection of the liver function, reduction of the cholesterol and bilirubin levels, and regulation of the inflammatory reactions. CHCs as treatments based on TCM can ameliorate the overall bodily function, thereby preventing the recurrence of cholelithiasis. Appropriate application of CHCs would be beneficial for patients and clinicians, although the safety and efficacy of CHCs need further verification.
胆结石是一个重大的公共卫生问题，需要高效、可行且能预防复发的治疗方法。目前可用的手术治疗和药物无法有效避免胆结石复发。因此，鉴于几种中药复方（CHCs）能有效排出胆结石并预防病情复发，它们被考虑用于治疗胆结石。在本叙述性综述中，我们旨在总结目前使用的中药复方治疗胆结石的潜在机制，并描述中医治疗胆结石的现状。使用了几种常用的中药复方来说明这些问题。我们发现，中药复方治疗的机制依赖于改善胆汁动力学因素、维持和保护肝功能、降低胆固醇和胆红素水平以及调节炎症反应。基于中医的中药复方治疗可以改善整体身体功能，从而预防胆结石复发。尽管中药复方的安全性和有效性需要进一步验证，但适当应用中药复方对患者和临床医生将是有益的。
