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透明质酸凝胶注射用于重建龈乳头的评估:一项随机临床试验

Assessment of Hyaluronic Acid Gel Injection in the Reconstruction of Interdental Papilla: A Randomized Clinical Trial.

作者信息

Abdelraouf Sara Amr, Dahab Omnia Aboul, Elbarbary Ahmed, El-Din Amany Mohy, Mostafa Basma

机构信息

Surgery and Oral Medicine Department, Oral and Dental Research Division, National Research Centre, Cairo, Egypt.

Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.

出版信息

Open Access Maced J Med Sci. 2019 Jun 14;7(11):1834-1840. doi: 10.3889/oamjms.2019.478. eCollection 2019 Jun 15.

DOI:10.3889/oamjms.2019.478
PMID:31316670
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6614259/
Abstract

BACKGROUND

Various techniques have been implemented to reconstruct the deficient interdental papilla.

AIM

The present trial was conducted to assess the effect of injection of hyaluronic acid gel for the reconstruction of deficient interdental papilla.

MATERIAL AND METHODS

Thirty-six deficient interdental papilla sites in ten patients were randomly allocated into two equal groups; intervention group who received the injection of hyaluronic acid (HA) gel and control group who received the injection of saline solution as a placebo. Each deficient papilla received three injections. The first injection was given one week following the re-evaluation period (four weeks after performing full mouth supra-gingival scaling and sub-gingival debridement). The second and third injections were given after three and six weeks, respectively. The height and surface area of black triangles were recorded at baseline before the injection procedures. The participants were recalled after three and six months from the first injection for re-measuring the recorded parameters. At 6 months, patients' satisfaction was also assessed.

RESULTS

After three and six months from baseline, the results revealed a statistically significant higher mean decrease in height and surface area of black triangles in favour of the HA group. From three to six months, there was no statistically significant difference between the two groups in both parameters. At 6 months, the HA group showed a statistically significant higher mean satisfaction score than the saline group.

CONCLUSION

The use of hyaluronic acid gel for the reconstruction of interdental papillary deficiency was effective with promising levels of patients' satisfaction.

摘要

背景

已采用多种技术来重建缺失的龈乳头。

目的

进行本试验以评估注射透明质酸凝胶对重建缺失龈乳头的效果。

材料与方法

将10例患者的36个缺失龈乳头部位随机分为两组,每组人数相等;干预组接受透明质酸(HA)凝胶注射,对照组接受生理盐水注射作为安慰剂。每个缺失乳头接受3次注射。第一次注射在重新评估期(全口龈上洁治和龈下刮治4周后)1周后进行。第二次和第三次注射分别在3周和6周后进行。在注射程序前的基线记录黑色三角区的高度和表面积。从第一次注射起3个月和6个月后对参与者进行回访,重新测量记录的参数。在6个月时,还评估了患者的满意度。

结果

与基线相比,3个月和6个月后,结果显示黑色三角区高度和表面积的平均减少量在HA组中具有统计学意义的更高值。从3个月到6个月,两组在这两个参数上均无统计学意义的差异。在6个月时,HA组的平均满意度得分在统计学上显著高于生理盐水组。

结论

使用透明质酸凝胶重建龈乳头缺损有效,患者满意度较高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fd/6614259/8ca49ae308c4/OAMJMS-7-1834-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fd/6614259/cf5e537488c4/OAMJMS-7-1834-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fd/6614259/9c22bd4a1bef/OAMJMS-7-1834-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fd/6614259/2e227028dddc/OAMJMS-7-1834-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fd/6614259/8ca49ae308c4/OAMJMS-7-1834-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fd/6614259/cf5e537488c4/OAMJMS-7-1834-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fd/6614259/9c22bd4a1bef/OAMJMS-7-1834-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fd/6614259/2e227028dddc/OAMJMS-7-1834-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fd/6614259/8ca49ae308c4/OAMJMS-7-1834-g004.jpg

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