Beck Tiffany L, Momose Hitomi, Dym Jeffrey M, Rao Vikas Y, Bohart Randy, Goldstein Bram H
Gynecologic Oncology Associates, Newport Beach, CA, United States of America.
St. Joseph Health, Department of Pathology, Mission Viejo, CA, United States of America.
Gynecol Oncol Rep. 2019 Jun 22;29:55-57. doi: 10.1016/j.gore.2019.06.006. eCollection 2019 Aug.
Dysgerminomas are aggressive germ cell tumors that typically have a favorable prognosis, especially in patients diagnosed with early stage disease. We recount the history of a 23-year-old woman who was treated for a stage IA ovarian dysgerminoma in November 2017. Postoperatively, the patient was noncompliant insofar as obtaining routine lab evaluations; ten months later, she was diagnosed with a cranial metastasis that extended into the meninges. The patient subsequently underwent a posterior fossa craniotomy and adjuvant etoposide, bleomycin and cisplatin chemotherapy to which she initially responded; however, during cycle 4, she developed pancytopenia whereupon the chemotherapy was summarily discontinued. Thereafter, the patient was surveilled and currently, she remains in clinical remission. Early stage ovarian dysgerminoma, albeit rarely, has the capacity to metastasize to the cranium or brain, further underscoring the significance of employing active follow-up with these patients.
无性细胞瘤是侵袭性生殖细胞肿瘤，通常预后良好，尤其是在诊断为早期疾病的患者中。我们讲述一名23岁女性的病史，她于2017年11月接受了IA期卵巢无性细胞瘤治疗。术后，患者在进行常规实验室评估方面不配合；十个月后，她被诊断出颅转移并累及脑膜。患者随后接受了后颅窝开颅手术及依托泊苷、博来霉素和顺铂辅助化疗，最初有反应；然而，在第4周期时，她出现全血细胞减少，化疗随即停止。此后，对患者进行监测，目前她仍处于临床缓解状态。早期卵巢无性细胞瘤，尽管罕见，但有转移至颅骨或脑部的可能，这进一步凸显了对这些患者进行积极随访的重要性。
