Amsterdam UMC, Vrije Universiteit, Psychiatry, Amsterdam Public Health Research Institute, The Netherlands.
GGZ inGeest Specialised Mental Health Care, Amsterdam, The Netherlands.
PLoS One. 2019 Jul 18;14(7):e0219588. doi: 10.1371/journal.pone.0219588. eCollection 2019.
Anxiety and depressive disorders are increasingly being viewed as chronic conditions with fluctuating symptom levels. Relapse prevention programmes are needed to increase self-management and prevent relapse. Fine-tuning relapse prevention programmes to the needs of patients may increase uptake and effectiveness.
A discrete choice experiment (DCE) was conducted amongst patients with a partially or fully remitted anxiety or depressive disorder. Patients were presented 20 choice tasks with two hypothetical treatment scenarios for relapse prevention, plus a "no treatment" option. Each treatment scenario was based on seven attributes of a hypothetical but realistic relapse prevention programme. Attributes considered professional contact frequency, treatment type, delivery mode, programme flexibility, a personal relapse prevention plan, time investment and effectiveness. Choice models were estimated to analyse the data.
A total of 109 patients with a partially or fully remitted anxiety or depressive disorder completed the DCE. Attributes with the strongest impact on choice were high effectiveness, regular contact with a professional, low time investment and the inclusion of a personal prevention plan. A high heterogeneity in preferences was observed, related to both clinical and demographic characteristics: for example, a higher number of previous treatment episodes was related to a preference for a higher frequency of contact with a professional, while younger age was related to a stronger preference for high effectiveness.
This study using a DCE provides insights into preferences for a relapse prevention programme for anxiety and depressive disorders that can be used to guide the development of such a programme.
焦虑和抑郁障碍越来越被视为具有波动症状水平的慢性疾病。需要预防复发的方案来增强自我管理能力并预防复发。根据患者的需求对预防复发方案进行微调可能会提高接受度和有效性。
在部分或完全缓解的焦虑或抑郁障碍患者中进行了离散选择实验(DCE)。向患者呈现了 20 个选择任务,涉及两种假设的预防复发治疗方案,外加“无治疗”选项。每个治疗方案都是基于假设但现实的预防复发方案的七个属性。考虑的属性包括专业联系频率、治疗类型、提供模式、方案灵活性、个人预防复发计划、时间投入和效果。使用选择模型来分析数据。
共有 109 名部分或完全缓解的焦虑或抑郁障碍患者完成了 DCE。对选择影响最大的属性是高效果、与专业人员定期联系、低时间投入和纳入个人预防计划。观察到偏好存在很大的异质性,与临床和人口统计学特征有关:例如,更多的先前治疗发作与对与专业人员更频繁联系的偏好有关,而年龄较小与对高效果的更强偏好有关。
本研究使用 DCE 提供了对焦虑和抑郁障碍预防复发方案偏好的见解,可用于指导此类方案的制定。