Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, P.O. Box: 143951374, Tehran, Iran.
Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, P.O. Box: 143951374, Tehran, Iran.
Carbohydr Polym. 2019 Oct 15;222:115033. doi: 10.1016/j.carbpol.2019.115033. Epub 2019 Jun 26.
Hyaluronic acid (HA), a naturally sourced polysaccharide, has shown remarkable effectiveness on wound healing, but its low mechanical strength and instability limits its frequent application in this field. In order to minimize this shortcoming, hyaluronic acid based wound dressings were blended with functionalized ZIF-8, which not only provides high mechanical strength, but also introduces antibacterial properties and promotes fibroblast migration and proliferation. To analyze physiochemical and biological characteristics of prepared wound dressings, tests including DLS, XRD, FTIR as well as antibacterial and cell adhesion assays were carried out. Results indicated that HA film modification boosted the Young's modulus from 138 to 176 K Pa, and reduced the water contact angle from 37.4 to 27.7 proving enhancement in hydrophilicity. Ameliorated antibacterial properties and better cell adhesion were also observed. Suitable cell viability was observed in samples with FZIF-8, since released Zn ions maintained within a safe concentration range.
透明质酸（HA）是一种天然来源的多糖，在伤口愈合方面表现出显著的效果，但它的机械强度低和不稳定性限制了其在该领域的频繁应用。为了最大限度地减少这一缺点，基于透明质酸的伤口敷料与功能化 ZIF-8 混合，这不仅提供了高机械强度，还引入了抗菌性能并促进成纤维细胞迁移和增殖。为了分析制备的伤口敷料的物理化学和生物学特性，进行了包括 DLS、XRD、FTIR 以及抗菌和细胞黏附测定在内的测试。结果表明，HA 薄膜改性将杨氏模量从 138 增加到 176 KPa，并将水接触角从 37.4 降低到 27.7，证明了亲水性的增强。还观察到抗菌性能的改善和更好的细胞黏附。在含有 FZIF-8 的样品中观察到合适的细胞活力，因为释放的 Zn 离子保持在安全浓度范围内。
